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Intrinsically Disordered Proteins

  • Vladimir N.¬†Uversky

Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)

Also part of the Protein Folding and Structure book sub series (BRIEFSPROTEIN)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Vladimir N. Uversky
    Pages 1-51
  3. Back Matter
    Pages 53-61

About this book

Introduction

In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Keywords

Binding Promiscuity Conformational Ensemble Intrinsically Disordered Protein Protein Folding Protein Function Structural Heterogeneity

Authors and affiliations

  • Vladimir N.¬†Uversky
    • 1
  1. 1.Department of Molecular MedicineUniversity of South FloridaTampaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-08921-8
  • Copyright Information The Author(s) 2014
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-08920-1
  • Online ISBN 978-3-319-08921-8
  • Series Print ISSN 2191-5407
  • Series Online ISSN 2191-5415
  • Buy this book on publisher's site
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