Overview
- Editors:
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Fernando Ferreira Costa
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Centro de Hematologia e Hemoterapia, Unicamp, Campinas, Brazil
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Nicola Conran
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Centro de Hematologia e Hemoterapia, Unicamp, Campinas, Brazil
An update on the medical literature regarding sickle cell disease
Provides scientific basis to explain the clinical aspects of sickle cell disease
Co-authored by international clinicians and scientists with years of experience in studying and managing the disease
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Table of contents (16 chapters)
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- Susan E. Jorge, Daniela M. Ribeiro, Magnun N. N. Santos, Maria de Fátima Sonati
Pages 1-22
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- Frédéric B. Piel, Thomas N. Williams
Pages 23-47
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- Nancy J. Wandersee, Cheryl A. Hillery
Pages 75-90
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- Dachuan Zhang, Paul S. Frenette
Pages 91-107
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- Marina Pereira Colella, Erich Vinicius de Paula, Margareth Castro Ozelo, Fabiola Traina
Pages 109-127
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- Lydia H. Pecker, Hans C. Ackerman
Pages 129-175
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- Camila Bononi de Almeida, Gregory J. Kato, Nicola Conran
Pages 177-211
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- Robert Sheppard Nickel, Lewis L. Hsu
Pages 213-229
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- Rouba Abdennour, Miguel R. Abboud
Pages 231-267
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- Mário A. Claudino, Carla F. Franco Penteado, Kleber Yotsumoto Fertrin
Pages 269-283
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- Fernando Ferreira Costa, Kleber Yotsumoto Fertrin
Pages 285-318
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- Sara T. Olalla Saad, Simone O. Gilli
Pages 319-337
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- Adekunle Adekile, Julie Makani
Pages 339-370
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- Kate Gardner, Swee Lay Thein
Pages 371-397
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- Kerri Nottage, Jeremie Estepp, Jane Hankins
Pages 399-429
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Back Matter
Pages 431-435
About this book
Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.
About the editors
Fernando F. Costa - graduated (1974) and obtained both his MSc (1979) and PhD (1981) degrees from the Ribeirão Preto School of Medicine of the University of São Paulo, where he also served as a faculty member (1985-1989). After completing a postdoctoral fellowship at the Yale School of Medicine (1987-1989), he joined the Department of Internal Medicine of the School of Medical Sciences of the University of Campinas (1990) and became a Full Professor of Hematology and Hemotherapy (1996). Member of several national and international academic societies, Professor Costa has already published 260 papers in peer-reviewed journals and supervised 29 doctoral theses. He received a decoration from the Government of Brazil (2008) and has been awarded a great number of scientific prizes, including one from the Government of the State of São Paulo (2000). At the University of Campinas, Professor Costa served as Dean of the School of Medical Sciences (1994-1998), Director of the Hematology and Hemotherapy Center (1998-2002), Vice-President for Research (2002-2005) and General Coordinator of the University (2005-2009). He was the president of the University of Campinas from April 2009 to April 2013.
Nicola Conran - Research scientist at the University of Campinas, Brazil. Graduated in Biochemistry (University of Birmingham, UK); PhD, University of Nottingham, UK.
