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MicroRNAs: Key Regulators of Oncogenesis

  • Sadegh Babashah

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. MicroRNAs: Biology and Implications in Cancer

    1. Front Matter
      Pages 1-1
    2. Sadegh Babashah
      Pages 3-28
    3. Jiazeng Xia, Xiaoqiang Guo, Kaiyuan Deng
      Pages 29-57
    4. Shahana Majid, Sumit Arora, Rajvir Dahiya, Sharanjot Saini
      Pages 59-82
    5. Linchong Sun, Xiaoping He, Yang Cao, Ping Gao, Huafeng Zhang
      Pages 83-95
    6. Gianpiero Di Leva, Michela Garofalo
      Pages 97-127
    7. Charles H. Lawrie
      Pages 129-153
    8. Muriel Thirion, Teru Kanda, Yoshiki Murakami, Takahiro Ochiya, Hisashi Iizasa
      Pages 155-182
    9. Angélique Gougelet, Sabine Colnot
      Pages 183-208
    10. Jun Wei, Yong Li, Xiaoming Liu, William C. Cho
      Pages 209-231
    11. Hugo Seca, Raquel T. Lima, M. Helena Vasconcelos
      Pages 251-293
    12. Bin Bao, Asfar S. Azmi, Aamir Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan Kong et al.
      Pages 295-320
  3. MicroRNAs and Their Clinical Implications

    1. Front Matter
      Pages 321-321
    2. Jürgen Wittmann
      Pages 323-353
    3. Manuela Ferracin, Laura Lupini
      Pages 355-367
    4. Kirsten Lindner, Joerg Haier, Richard Hummel
      Pages 369-386
    5. Babak Bakhshinejad, Mohammad Amin Javidi, Sahar Babashah, Sadegh Babashah
      Pages 387-411
    6. Yu Fujita, Kazuyoshi Kuwano, Takahiro Ochiya
      Pages 413-428
  4. Back Matter
    Pages 429-433

About this book

Introduction

Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs play a momentous role in oncogenesis via regulating cell proliferation and apoptosis as oncogenes or tumour suppressors. Expression signatures of miRNAs offer exciting opportunities for crafting cutting edge strategies in the diagnosis, prognosis, and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in the tortuous route of oncogenesis, the promise represented by using these small RNAs as therapeutic targets presents new perspectives to the landscape of cancer therapy by either inhibiting or augmenting their activity. This book devotes efforts to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of miRNAs found to be associated with cancer pathogenesis and possible mechanisms underlying the substantial roles played by miRNAs in cancer development and progression. Also, it intends to pave the way for readers to gain novel insights into using miRNAs as cancer biomarkers and therapeutic platforms.

Keywords

Diagnosis MicoRNA Oncogene Therapy Tumor suppressor

Editors and affiliations

  • Sadegh Babashah
    • 1
  1. 1.Dept. of Molec. Genetics, Fac. of Biological SciencesTarbiat Modares UniversityTehranIran

Bibliographic information

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