Hormones, Intrauterine Health and Programming

  • Jonathan R Seckl
  • Yves Christen

Part of the Research and Perspectives in Endocrine Interactions book series (RPEI, volume 12)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Louise C. Kenny, Claire Everard, Ali S. Khashan
    Pages 41-55
  3. John Challis, Debora Sloboda, Shaofu Li, Thorsten Braun, Frank Bloomfield, Ghazala Begum et al.
    Pages 57-69
  4. Anne Gabory, Alexandre Vigé, Laure Ferry, Linda Attig, Jean-Philippe Jais, Luc Jouneau et al.
    Pages 71-91
  5. C. Gicquel, S. Azzi, S. Rossignol, J. Demars, F. Brioude, I. Netchine et al.
    Pages 101-129
  6. Patricia P. Silveira, James L. Kennedy, Marla B. Sokolowski, Robert D. Levitan, Michael J. Meaney
    Pages 157-174
  7. M. A. Hanson, P. D. Gluckman, K. M. Godfrey
    Pages 175-183
  8. Back Matter
    Pages 185-189

About this book

Introduction

The environment of the fetus in the womb is emerging as a key determinant not only of its immediate status but also of the offspring’s long-term well-being. This largely started with reports of striking epidemiological associations between lower, but still normal, birth weight and a marked increase in the incidence of cardiac, metabolic and neuropsychiatric disorders from childhood to senescence. In seeking to explain these observations, collectively referred to as ‘developmental programming,’ a new subfield of biology has emerged. Major discoveries include detailing the etiological roles of maternal factors such as nutrition, inflammatory disease, stress and psychopathology. Key biochemical mediators have been discovered, notably including hormones such as glucocorticoids, which act on both the fetus and the placenta to change the trajectory of growth, tissue maturation and the expression of specific genes in affected cells. Such persisting changes in the transcription of genes may be in part underpinned by epigenetic changes. The mechanisms of these effects are beginning to emerge and offer the prospect of new diagnostics, biomarkers and potential therapeutic targets. This work provides an accessible and cutting-edge view of this rapidly emerging field.

Keywords

early life programming epigenetic dysregulation fetal development glucocorticoids maternal stress non-communicable diseases

Editors and affiliations

  • Jonathan R Seckl
    • 1
  • Yves Christen
    • 2
  1. 1.Endocrinology UnitUniversity of Edinburgh Queen's Medical Research InstEdinburghUnited Kingdom
  2. 2.Fondation IPSENBoulogne-Billancourt CedexFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-02591-9
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-02590-2
  • Online ISBN 978-3-319-02591-9
  • Series Print ISSN 1861-2253
  • Series Online ISSN 1863-0685
  • About this book
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