A Practical Guide to Drug Development in Academia

The SPARK Approach

  • Daria Mochly-Rosen
  • Kevin Grimes

Table of contents

  1. Front Matter
    Pages i-xii
  2. Daria Mochly-Rosen, Kevin Grimes
    Pages 1-29
  3. Daria Mochly-Rosen, Kevin Grimes
    Pages 31-77
  4. Daria Mochly-Rosen, Kevin Grimes
    Pages 79-108
  5. Daria Mochly-Rosen, Kevin Grimes
    Pages 109-125
  6. Daria Mochly-Rosen, Kevin Grimes
    Pages 127-162
  7. Daria Mochly-Rosen, Kevin Grimes
    Pages 163-170
  8. Back Matter
    Pages 171-176

About this book

Introduction

"A lot of hard-won knowledge is laid out here in a brief but informative way. Every topic is well referenced, with citations from both the primary literature and relevant resources from the internet." Review from Nature Chemical Biology

Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed ‘too early’ to attract industry interest. There are simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest. Each chapter broadly discusses an important topic in drug development, from preclinical work in assay design through clinical trial design, regulatory issues and marketing assessments. After the practical overview provided here, the reader is encouraged to consult more detailed texts on specific topics of interest.

"I would actually welcome it if this book’s intended audience were broadened even more. Younger scientists starting out in the drug industry would benefit from reading it and getting some early exposure to parts of the process that they’ll eventually have to understand. Journalists covering the industry (especially the small startup companies) will find this book a good reality check for many an over-hopeful press release. Even advanced investors who might want to know what really happens in the labs will find information here that might otherwise be difficult to track down in such a concentrated form."

Keywords

academia assay design clinical trial preclinical

Editors and affiliations

  • Daria Mochly-Rosen
    • 1
  • Kevin Grimes
    • 2
  1. 1.Dept. of Chemical and Systems BiologyStanford University School of MedicineStanfordUSA
  2. 2.Dept. of Chemical and Systems BiologyStanford University School of MedicineStanfordUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-02201-7
  • Copyright Information The Editors 2014
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-02200-0
  • Online ISBN 978-3-319-02201-7
  • Series Print ISSN 1864-8118
  • Series Online ISSN 1864-8126
  • About this book
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