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Birkhäuser

Proteases New Perspectives

  • Book
  • © 1999

Overview

Editors:
  1. Vito Turk

    1. Jozef Stefan Institute, Ljubljana, Slovenia

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Part of the book series: Molecular and Cell Biology Updates (MCBU)

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-IX
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  2. Peptidases: a view of classification and nomenclature

    • Alan J. Barrett
    Pages 1-12

  3. Carboxypeptidases

    • Josep Vendrell, Francesc X. AvilĂ©s
    Pages 13-34

  4. Signal peptidases

    • Mark O. Lively, Christopher M. Ashwell
    Pages 35-43

  5. Proteasomes

    • A. Jennifer Rivett, Grant G. F. Mason
    Pages 45-57

  6. Cathepsin E and cathepsin D

    • Kenji Yamamoto
    Pages 59-71

  7. Cell-associated metalloproteinases

    • Gary D. Johnson, Judith S. Bond
    Pages 73-93

  8. Proteinases in parasites

    • Juan JosĂ© Cazzulo
    Pages 95-107

  9. Cell-surface proteases in cancer

    • Lisa L. Demchik, Bonnie F. Sloane
    Pages 109-124

  10. Insect proteinases

    • Gerald Reeck, Brenda Oppert, Michael Denton, Michael Kanost, James Baker, Karl Kramer
    Pages 125-148

  11. Alzheimer’s disease and proteinases

    • Shoichi Ishiura
    Pages 149-158

  12. Calpains: structure and function of the calpain super family

    • Yasuko Ono, Hiroyuki Sorimachi, Koichi Suzuki
    Pages 159-174

  13. Arg-gingipain and Lys-gingipain: a novel class of cysteine proteinases

    • Kenji Yamamoto, Tomoko Kadowaki, Kuniaki Okamoto
    Pages 175-184

  14. Proteinases in apoptosis

    • Masanori Tomioka, Seiichi Kawashima
    Pages 185-193

  15. Caspases: cytokine activators and promoters of cell death

    • Guy S. Salvesen, Henning R. Stennicke
    Pages 195-210

  16. Lysosomal cysteine proteinases: Structure and regulation

    • Vito Turk, Gregor GunÄŤar, Dušan Turk
    Pages 211-224

  17. Back Matter

    Pages 225-238
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Keywords

About this book

This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.

Editors and Affiliations

  • Jozef Stefan Institute, Ljubljana, Slovenia

    Vito Turk

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