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Birkhäuser

Mechanisms and Mediators of Neuropathic Pain

  • Book
  • © 2002

Overview

Editors:
  1. Annika B. Malmberg

    1. NeurogesX, Inc., San Carlos, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Sandra R. Chaplan

    1. RW Johnson Pharmaceutical Institute, San Diego, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xii
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  2. Peripheral consequences of nerve injury

    1. Front Matter

      Pages 1-1
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    2. Electrophysiological characteristics of injured peripheral nerves

      • Martin Michaelis
      Pages 3-22

    3. Sodium channels and the molecular basis for pain

      • Joel A. Black, Theodore R. Cummins, Sulayman D. Dib-Hajj, Stephen G. Waxman
      Pages 23-50

    4. Changes in DRG neurons after injury: possible involvement in the development and maintenance of neuropathic pain

      • Valerie M. K. Verge, Tracy D. Wilson-Gerwing, Laurie A. Karchewski, Kelly A. Gratto
      Pages 51-65

    5. Neuroinflammation, cytokines and neuropathic pain

      • Linda S. Sorkin
      Pages 67-75

  3. Spinal cord plasticity following peripheral nerve injury

    1. Front Matter

      Pages 77-77
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    2. Pharmacological plasticity associated with neuropathic pain states

      • Victoria Chapman, Anthony H. Dickenson
      Pages 79-87

    3. Sprouting and reorganization in the spinal cord after nerve injury

      • Susan M. Carlton, Richard E. Coggeshall
      Pages 89-106

  4. Neuropathic pain: preclinical and clinical paradigms

    1. Front Matter

      Pages 107-107
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    2. Pre-clinical nerve ligation models: behavior and electrophysiology

      • Jin Mo Chung, Kyungsoon Chung
      Pages 109-125

    3. Animal models of toxic and metabolic sensory neuropathies

      • Nigel A. Calcutt, Jason D. Freshwater
      Pages 127-152

    4. Role of adrenergic transmitters and receptors in nerve and tissue injury related pain

      • Ralf Baron, Srinivasa N. Raja
      Pages 153-174

    5. Evaluation of neuropathic pain

      • Karen M. Park, Richard H. Gracely
      Pages 175-197

  5. New treatment strategies for neuropathic pain

    1. Front Matter

      Pages 199-199
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    2. Glutamate receptor antagonists and neuropathic pain

      • Per Kristian Eide
      Pages 201-209

    3. Antiepileptic drugs for treatment of neuropathic pain

      • Charles P. Taylor
      Pages 211-232

    4. Calcium channel antagonists for the treatment of pain

      • Mark S. Wallace
      Pages 233-243

    5. Cholinergic, adenosinergic and a2 adrenergic mechanisms in chronic neuropathic pain

      • Hartmut Buerkle, Stuart A. Dunbar
      Pages 245-253

  6. Back Matter

    Pages 255-260
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Keywords

About this book

Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initiates a cascade of events resulting in altered neurochemistry and molecular biology of the peripheral neurons, the dorsal root ganglion cell, and changes in neurotransmitter and receptor expression in the dorsal horn of the spinal cord. Moreover, nerve injury produces anatomical changes with functional consequences.
This volume summarises the current understanding of the pathophysiological processes in the peripheral and central nervous system that contribute to the neuropathic pain. It provides a timely review of neuropathic pain mechanisms, written by experts in the field.

Editors and Affiliations

  • NeurogesX, Inc., San Carlos, USA

    Annika B. Malmberg

  • RW Johnson Pharmaceutical Institute, San Diego, USA

    Sandra R. Chaplan

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