Notch Signaling in Embryology and Cancer

Notch Signaling in Cancer

  • Jörg Reichrath
  • Sandra Reichrath

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1287)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Benedetto Daniele Giaimo, Ellen K. Gagliani, Rhett A. Kovall, Tilman Borggrefe
    Pages 9-30
  3. Violeta Jonusiene, Ausra Sasnauskiene
    Pages 47-57
  4. Yong Li, Yahui Li, Xiaoxin Chen
    Pages 59-68
  5. Kazunori Kawaguchi, Shuichi Kaneko
    Pages 69-80
  6. Cristina Porcheri, Thimios A. Mitsiadis
    Pages 81-103
  7. Trianth Das, Rong Zhong, Michael T. Spiotto
    Pages 105-122
  8. Rachael Guenter, Zeelu Patel, Herbert Chen
    Pages 155-168
  9. Fasoulakis Zacharias, Daskalakis George, Theodora Marianna, Antsaklis Panos, Sindos Michael, Diakosavvas Michail et al.
    Pages 169-181
  10. Qiang Shen, Michael Reedijk
    Pages 183-200
  11. Back Matter
    Pages 223-228

About this book


This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more.

Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling – this is a definitive discussion of the topic, presented by internationally-recognized contributors.  Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.


Notch Notch Signaling Embryology Microbiome and Cancer Notch and senescence Regulation of Notch Signaling Cancer Stem Cells Stem Cell Niche

Editors and affiliations

  • Jörg Reichrath
    • 1
  • Sandra Reichrath
    • 2
  1. 1.Department of DermatologySaarland University Medical CenterHomburgGermany
  2. 2.School of Health Professions, Saarland University Medical CenterDepartment of Dermatology, Saarland University Medical CenterHomburgGermany

Bibliographic information

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