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Neuroinflammation and Schizophrenia

  • Book
  • © 2020

Overview

Editors:
  1. Golam M. Khandaker

    1. Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK

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  2. Urs Meyer

    1. Verhaltensneurobiologie, ETH Zürich, Schwerzenbach, Switzerland

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  3. Peter B. Jones

    1. Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK

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  • Provides a comprehensive summary of the scientific evidence regarding the role of immune system in the pathogenesis and treatment of schizophrenia and related psychoses
  • Covers both basic science and clinical research
  • Supplies valuable recommendations for clinical practice and testable hypotheses for future research

Part of the book series: Current Topics in Behavioral Neurosciences (CTBN, volume 44)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
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  2. A Brief History of Immunological Research into Psychosis and Pathways for Immune Influence of the Brain

    • Norbert Müller
    Pages 1-8

  3. Basic Concept of Microglia Biology and Neuroinflammation in Relation to Psychiatry

    • Daniele Mattei, Tina Notter
    Pages 9-34

  4. Epidemiological Studies of Prenatal and Childhood Infection and Schizophrenia

    • Håkan Karlsson, Christina Dalman
    Pages 35-47

  5. Cytokines, Oxidative Stress and Cellular Markers of Inflammation in Schizophrenia

    • Rachel Upthegrove, Golam M. Khandaker
    Pages 49-66

  6. From Infection to the Microbiome: An Evolving Role of Microbes in Schizophrenia

    • Emily G. Severance, Robert H. Yolken
    Pages 67-84

  7. Autoantibodies and Psychosis

    • Eric Kelleher, Helen Barry, David R. Cotter, Aiden Corvin, Kieran C. Murphy
    Pages 85-123

  8. Herpes Simplex Virus Type-1 Infection: Associations with Inflammation and Cognitive Aging in Relation to Schizophrenia

    • Vishwajit L. Nimgaonkar, Triptish Bhatia, Abdelaziz Mansour, Maribeth A. Wesesky, Smita Deshpande
    Pages 125-139

  9. Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies

    • Michael E. Benros, Preben B. Mortensen
    Pages 141-159

  10. Microglial Activation and Psychotic Disorders: Evidence from Pre-clinical and Clinical Studies

    • Tatiana Barichello, Lutiana R. Simoes, Joao Quevedo, Xiang Y. Zhang
    Pages 161-205

  11. Early-Life Adversity, Systemic Inflammation and Comorbid Physical and Psychiatric Illnesses of Adult Life

    • Maria Antonietta Nettis, Carmine M. Pariante, Valeria Mondelli
    Pages 207-225

  12. Inflammation, Antipsychotic Drugs, and Evidence for Effectiveness of Anti-inflammatory Agents in Schizophrenia

    • Ananda K. Pandurangi, Peter F. Buckley
    Pages 227-244
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Keywords

About this book

This book provides a comprehensive summary of the cutting edge scientific evidence regarding the role of immune system in the pathogenesis and treatment of schizophrenia and related psychotic disorders. It illustrates the role of inflammation and immunity in schizophrenia drawing on both basic science and clinical research. The chapters provide up-to-date summaries of immunological risk factors for schizophrenia and related psychotic disorders, and underlying mechanisms as informed by neuroimaging, genetic, clinical and animal experimental studies. In addition, the book will illuminate the scope for immunological treatment for schizophrenia. 

Editors and Affiliations

  • Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK

    Golam M. Khandaker, Peter B. Jones

  • Verhaltensneurobiologie, ETH Zürich, Schwerzenbach, Switzerland

    Urs Meyer

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