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Concepts and Principles of Pharmacology

100 Years of the Handbook of Experimental Pharmacology

  • Book
  • © 2019

Overview

Editors:
  1. James E. Barrett

    1. Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, USA

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  2. Clive P. Page

    1. Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, London, UK

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    You can also search for this editor in PubMed   Google Scholar

  3. Martin C. Michel

    1. Department of Pharmacology, Johannes Gutenberg University, Mainz, Rheinland-Pfalz, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • Broadens the understanding of past and present pharmacology as basis of future treatments
  • Reinforces basic principles of pharmacology as the foundation of modern drug discovery
  • Enriches understanding of the history of pharmacology

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 260)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-viii
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  2. Perspectives of Pharmacology over the Past 100 Years

    • James E. Barrett, Clive Page, Martin C. Michel
    Pages 3-16

  3. Emergent Concepts of Receptor Pharmacology

    • Terry Kenakin
    Pages 17-41

  4. The Evolving Landscape of Cancer Therapeutics

    • Madeha Khan, James Spicer
    Pages 43-79

  5. Monoclonal Antibodies: Past, Present and Future

    • J. Posner, P. Barrington, T. Brier, A. Datta-Mannan
    Pages 81-141

  6. 100 Years of Drug Delivery to the Lungs

    • Federico Lavorini, Francesca Buttini, Omar S. Usmani
    Pages 143-159

  7. Ion Channel Pharmacology for Pain Modulation

    • Francesco De Logu, Pierangelo Geppetti
    Pages 161-186

  8. Exploiting the Diversity of Ion Channels: Modulation of Ion Channels for Therapeutic Indications

    • Yani Liu, KeWei Wang
    Pages 187-205

  9. Genetically Encoded Fluorescent Calcium and Voltage Indicators

    • Irene Mollinedo-Gajate, Chenchen Song, Thomas Knöpfel
    Pages 209-229

  10. Mechanistic Image-Based Modelling: Concepts and Applications

    • Denis Menshykau, Simon Tanaka
    Pages 231-261

  11. Pharmacometabonomics: The Prediction of Drug Effects Using Metabolic Profiling

    • Jeremy R. Everett
    Pages 263-299

  12. The Microbiome and Its Potential for Pharmacology

    • Aries Chavira, Pedro Belda-Ferre, Tomasz Kosciolek, Farhana Ali, Pieter C. Dorrestein, Rob Knight
    Pages 301-326

  13. Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology

    • D. Lansing Taylor, Albert Gough, Mark E. Schurdak, Lawrence Vernetti, Chakra S. Chennubhotla, Daniel Lefever et al.
    Pages 327-367

  14. The Future of Clinical Trial Design: The Transition from Hard Endpoints to Value-Based Endpoints

    • Matthijs D. Kruizinga, Frederik E. Stuurman, Geert J. Groeneveld, Adam F. Cohen
    Pages 371-397

  15. Placebos and the Placebo Effect in Drug Trials

    • Paul Enck, Sibylle Klosterhalfen
    Pages 399-431

  16. Pharmacoepidemiology

    • Nicholas Moore, Patrick Blin, Cécile Droz
    Pages 433-451

  17. Why Are New Drugs Expensive and How Can They Stay Affordable?

    • Basma Hammel, Martin C. Michel
    Pages 453-466
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Keywords

About this book

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Editors and Affiliations

  • Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, USA

    James E. Barrett

  • Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, London, UK

    Clive P. Page

  • Department of Pharmacology, Johannes Gutenberg University, Mainz, Rheinland-Pfalz, Germany

    Martin C. Michel

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