© 2020

Good Research Practice in Non-Clinical Pharmacology and Biomedicine

  • Anton Bespalov
  • Martin C. Michel
  • Thomas Steckler
  • First comprehensive book on factors associated with high risk for poor reproducibility of non-clinical findings

  • Inclusion of aspects of study design, data analysis and data reporting

  • Broad applicability to in vitro and in vivo research across all therapeutic areas

Open Access

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 257)

Table of contents

  1. Front Matter
    Pages i-x
  2. Sandrine Bongiovanni, Robert Purdue, Oleg Kornienko, René Bernard
    Pages 1-17 Open Access
  3. Patricia Kabitzke, Kristin M. Cheng, Bruce Altevogt
    Pages 19-34 Open Access
  4. Isabel A. Lefevre, Rita J. Balice-Gordon
    Pages 35-54 Open Access
  5. Wenlong Huang, Nathalie Percie du Sert, Jan Vollert, Andrew S. C. Rice
    Pages 55-69 Open Access
  6. Anton Bespalov, Karsten Wicke, Vincent Castagné
    Pages 81-100 Open Access
  7. Dario Doller, Paul Wes
    Pages 119-145 Open Access
  8. Stacey J. Sukoff Rizzo, Stephanie McTighe, David L. McKinzie
    Pages 147-162 Open Access
  9. Betül R. Erdogan, Martin C. Michel
    Pages 163-175 Open Access
  10. Christoph H. Emmerich, Christopher M. Harris
    Pages 177-196 Open Access
  11. Patrizia Voehringer, Janet R. Nicholson
    Pages 197-222 Open Access
  12. Michael J. Lew
    Pages 223-256 Open Access
  13. Björn Gerlach, Christopher Untucht, Alfred Stefan
    Pages 257-275 Open Access
  14. Christopher Frederick Isambard Blumzon, Adrian-Tudor Pănescu
    Pages 277-297 Open Access
  15. Malcolm R. Macleod, Ezgi Tanriver-Ayder, Kaitlyn Hair, Emily Sena
    Pages 299-317 Open Access
  16. Anja Gilis
    Pages 349-365 Open Access
  17. Javier Guillén, Thomas Steckler
    Pages 367-382 Open Access

About this book


This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.


reproducibility study design data analysis data reporting data integrity quality management open access

Editors and affiliations

  • Anton Bespalov
    • 1
  • Martin C. Michel
    • 2
  • Thomas Steckler
    • 3
  1. 1.Partnership for Assessment & Accreditation of Scientific PracticeHeidelbergGermany
  2. 2.Department of PharmacologyJohannes Gutenberg UniversityMainzGermany
  3. 3.Janssen Pharmaceutica N.V.BeerseBelgium

Bibliographic information

  • Book Title Good Research Practice in Non-Clinical Pharmacology and Biomedicine
  • Editors Anton Bespalov
    Martin C. Michel
    Thomas Steckler
  • Series Title Handbook of Experimental Pharmacology
  • Series Abbreviated Title Hdb Exp.Pharmacology(formerly:Starke,K.:Eds)
  • DOI
  • Copyright Information The Editor(s) (if applicable) and The Author(s) 2020
  • License CC BY
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-33655-4
  • Softcover ISBN 978-3-030-33658-5
  • eBook ISBN 978-3-030-33656-1
  • Series ISSN 0171-2004
  • Series E-ISSN 1865-0325
  • Edition Number 1
  • Number of Pages X, 423
  • Number of Illustrations 13 b/w illustrations, 21 illustrations in colour
  • Topics Pharmacology/Toxicology
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