Overview
- Provides the fundamental basic and applied clinical science at the cutting edge of CSS treatment
- First textbook devoted to Cytokine Storm Syndromes, covering all aspects of the disorder (clinical, genetics, pathophysiology, associations, therapy, and others)
- Extensive panel of contributing authors, made up of internationally-renowned experts in CSS research
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Table of contents (35 chapters)
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Front Matter
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Genetics of Cytokine Storm Syndromes
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Front Matter
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Immunology of Cytokine Storm Syndromes
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Front Matter
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Infectious Triggers of Cytokine Storm Syndromes
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Front Matter
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Keywords
About this book
Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals.
A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research,to clinical presentations, risk factors, and treatment.
Editors and Affiliations
About the editors
Randy Q. Cron, MD, PhD
University of Alabama at Birmingham
Professor of Pediatrics and Medicine
Birmingham
Alabama
USA
Edward M. Behrens, MD
University of Pennsylvania Perelman School of Medicine
Perelman School of Medicine
Philadelphia
Pennsylvania
USA
Bibliographic Information
Book Title: Cytokine Storm Syndrome
Editors: Randy Q. Cron, Edward M. Behrens
DOI: https://doi.org/10.1007/978-3-030-22094-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-22093-8Published: 20 September 2019
Softcover ISBN: 978-3-030-22096-9Published: 20 September 2020
eBook ISBN: 978-3-030-22094-5Published: 09 September 2019
Edition Number: 1
Number of Pages: XXI, 617
Number of Illustrations: 6 b/w illustrations, 25 illustrations in colour
Topics: Immunology, Cytogenetics, Infectious Diseases, Cytokines and Growth Factors
Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma