Ovarian Cancer

Methods and Protocols

  • Anastasia Malek
  • Oleg Tchernitsa

Part of the Methods in Molecular Biology book series (MIMB, volume 1049)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Evaluation of Genomic Alteration

    1. Front Matter
      Pages 1-1
    2. Evgeny N. Imyanitov
      Pages 3-7
    3. Joshy George, Kylie L. Gorringe, Gordon K. Smyth, David D. L. Bowtell
      Pages 9-19
    4. Qiong Lin, Wolfgang Wagner, Martin Zenke
      Pages 21-33
    5. Kazimierz O. Wrzeszczynski, Vinay Varadan, Sitharthan Kamalakaran, Douglas A. Levine, Nevenka Dimitrova, Robert Lucito
      Pages 35-51
    6. Mine S. Cicek, Matthew J. Maurer, Ellen L. Goode
      Pages 53-64
  3. Targeted Analysis of DNA Methylation

    1. Front Matter
      Pages 65-65
    2. Susan K. Murphy, Christopher F. Bassil, Zhiqing Huang
      Pages 67-74
    3. Zhiqing Huang, Christopher F. Bassil, Susan K. Murphy
      Pages 75-82
    4. Zhiqing Huang, Christopher F. Bassil, Susan K. Murphy
      Pages 83-94
    5. Christopher F. Bassil, Zhiqing Huang, Susan K. Murphy
      Pages 95-107
  4. Gene/Genome Expression Assessing

    1. Front Matter
      Pages 109-109
    2. Anastasia Malek
      Pages 111-117
    3. Juan Cui, Ying Xu, David Puett
      Pages 119-137
    4. Lisha Li, Jie Liu, Wei Yu, Xiaoyan Lou, Bingding Huang, Biaoyang Lin
      Pages 139-169
    5. Ileabett M. Echevarria Vargas, Pablo E. Vivas-Mejía
      Pages 171-186
    6. Marilena V. Iorio, Carlo M. Croce
      Pages 187-197

About this book


Ovarian cancer is the most lethal malignancy of the female reproductive system and is also the fifth leading cause of cancer death in women. Sharing common characteristics of cancer, ovarian malignancy possess several clinical and biological particularities  In Ovarian Cancer: Methods and Protocols, expert researchers in the field provide methods that have been created or adapted to study various aspects of ovarian cancer. These methods and techniques are applicable to study genetic alterations present in ovarian cancer, structural and metabolic features of ovarian cancer cells, include  in vitro and in vivo models that recapitulate ovarian cancer development and progression, and describe ovarian cancer-oriented drug delivery approaches. Methodological chapters are grouped into seven thematic parts, any of them is introduced by short subject review. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.



Authoritative and practical, Ovarian Cancer: Methods and Protocols seeks to aid scientist to optimize study designs, to correctly select the most applicable methods, and to produce interesting and novel results.


In vitro and in vivo models Ovarian cancer cancer-oriented drug delivery research female gene methylation genome expression glycosides lipids malignant properties molecular biology techniques regulatory gene expression reproductive system structural genetic alterations

Editors and affiliations

  • Anastasia Malek
    • 1
  • Oleg Tchernitsa
    • 2
  1. 1.Group of Experimental TherapeuticsFederal State Institution N.N.Petrov Res Institute of OncologySt. PetersburgRussia
  2. 2.Labs of Molecular Tumor Pathology & FuncCharité - Universitatsmedizin BerlinBerlinGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-62703-547-7
  • Copyright Information Springer Science+Business Media, New York 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-546-0
  • Online ISBN 978-1-62703-547-7
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book
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