Antibody-Drug Conjugates

  • Laurent Ducry
Part of the Methods in Molecular Biology book series (MIMB, volume 1045)

Table of contents

  1. Front Matter
    Pages i-x
  2. Ingrid Sassoon, Véronique Blanc
    Pages 1-27
  3. Jan Anderl, Heinz Faulstich, Torsten Hechler, Michael Kulke
    Pages 51-70
  4. Pierre-Yves Abecassis, Céline Amara
    Pages 101-116
  5. Kedan Lin, Jay Tibbitts, Ben-Quan Shen
    Pages 117-131
  6. Miriam I. Hensgen, Bernhard Stump
    Pages 133-143
  7. James E. Stefano, Michelle Busch, Lihui Hou, Anna Park, Diego A. Gianolio
    Pages 145-171
  8. Marie-Priscille Brun, Laurence Gauzy-Lazo
    Pages 173-187
  9. Sunil Bhakta, Helga Raab, Jagath R. Junutula
    Pages 189-203
  10. Patrick Dennler, Roger Schibli, Eliane Fischer
    Pages 205-215
  11. William J. Galush, Aditya A. Wakankar
    Pages 217-233
  12. Bernhard Stump, Jessica Steinmann
    Pages 235-248
  13. Anil Wagh, Benedict Law
    Pages 249-266

About this book

Introduction

Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs.  In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion.  Written in the highly successful Methods in Molecular Biology™ format, these detailed chapters include the kind of practical implementation advice that guarantees quality results.

 

Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.

Keywords

ADCs Anti-cancer biotherapeutics Antigen-targeting Cancer treatment Immunoconjugates Monoclonal antibodies Tumor therapies

Editors and affiliations

  • Laurent Ducry
    • 1
  1. 1.Lonza LtdVispSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-62703-541-5
  • Copyright Information Springer Science+Business Media, LLC 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-540-8
  • Online ISBN 978-1-62703-541-5
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book

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