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RNA Therapeutics

Function, Design, and Delivery

  • Mouldy Sioud

Part of the Methods in Molecular Biology book series (MIMB, volume 629)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. John Karijolich, Athena Kantartzis, Yi-Tao Yu
    Pages 1-19
  3. John Karijolich, Athena Kantartzis, Yi-Tao Yu
    Pages 21-32
  4. Weiwei Gao, Zeyu Xiao, Alex Radovic-Moreno, Jinjun Shi, Robert Langer, Omid C. Farokhzad
    Pages 53-67
  5. Dag R. Sørensen, Mouldy Sioud
    Pages 85-89
  6. Wolfgang Walther, Ulrike Stein, Hermann Lage
    Pages 121-137
  7. Debra J. Taxman, Chris B. Moore, Elizabeth H. Guthrie, Max Tze-Han Huang
    Pages 139-156
  8. Sheena M. Saayman, Patrick Arbuthnot, Marc S. Weinberg
    Pages 157-172
  9. Christina Sæten Fjeldbo, Kristine Misund, Clara-Cecilie Günther, Mette Langaas, Tonje Strømmen Steigedal, Liv Thommesen et al.
    Pages 173-189
  10. Reiko Onuki-Nagasaki, Akira Nagasaki, Kazumi Hakamada, Taro Q.P. Uyeda, Satoshi Fujita, Masato Miyake et al.
    Pages 191-201
  11. Shao-Yao Ying, Chen Pu Chang, Shi-Lung Lin
    Pages 203-235
  12. Anders Fjose, Xiao-Feng Zhao
    Pages 237-253
  13. Mouldy Sioud, Lina Cekaite
    Pages 255-269
  14. Seungil Ro, Wei Yan
    Pages 271-283
  15. Rui Song, Seungil Ro, Wei Yan
    Pages 285-292
  16. Guillermo Aquino-Jarquin, Ramiro Rojas-Hernández, Luis Marat Alvarez-Salas
    Pages 321-336
  17. Yong Bai, Paul Jay Fannin Rider, Fenyong Liu
    Pages 337-351
  18. Ling Meng, Kwame Sefah, Dalia Lopez Colon, Hui Chen, Meghan O’Donoghue, Xiangling Xiong et al.
    Pages 353-365
  19. Weihua Pan, Gary A. Clawson
    Pages 367-383
  20. Mouldy Sioud
    Pages 385-392
  21. An M.T. Van Nuffel, Jurgen Corthals, Bart Neyns, Carlo Heirman, Kris Thielemans, Aude Bonehill
    Pages 403-450
  22. Hilde Almåsbak, Marianne Lundby, Anne-Marie Rasmussen
    Pages 451-491
  23. Mouldy Sioud
    Pages 493-503
  24. Back Matter
    Pages 523-526

About this book

Introduction

Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular Biology™ series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes.

Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.

Keywords

DNA Microarray PCR Transplantat Tumor cloning gene expression genes hybridization miRNAs molecular biology

Editors and affiliations

  • Mouldy Sioud
    • 1
  1. 1.Institute for Cancer Research, Dept. ImmunologyNorwegian Radium HospitalMontebello, OsloNorway

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60761-657-3
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-656-6
  • Online ISBN 978-1-60761-657-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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