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Heart Failure

Bench to Bedside

  • Book
  • © 2010

Overview

Authors:
  1. José Marín-García

    1. Neuromuscular Institute, Molecular Cardiology &, Highland Park, USA

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  • Comprehensive and critical evaluation of the multiple roles that molecular medicine plays in HF
  • Provides a definitive sense of future approaches in which molecular medicine might further be applied
  • Presents thorough discussions on molecular, cellular and metabolic changes occurring in HF
  • Includes supplementary material: sn.pub/extras

Part of the book series: Contemporary Cardiology (CONCARD)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xi
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  2. Clinical, Physiology and Genetics Changes in Heart Failure

    1. Front Matter

      Pages 1-1
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    2. Introduction to Heart Failure

      • José Marín-García
      Pages 3-13

    3. Cardiac Function in Heart Failure: The Role of Calcium Cycling

      • José Marín-García
      Pages 15-21

    4. Gene Profiling of the Failing Heart: Epigenetics

      • José Marín-García
      Pages 23-42

  3. Biochemical and Molecular Changes in Heart Failure

    1. Front Matter

      Pages 44-44
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    2. Bioenergetics and Metabolic Changes in the Failing Heart

      • José Marín-García
      Pages 45-69

  4. The Mitochondrial Organelle and the Heart

    1. Front Matter

      Pages 72-72
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    2. The Multidimensional Role of Mitochondria in Heart Failure

      • José Marín-García
      Pages 73-106

  5. Experimental Models of Heart Failure

    1. Front Matter

      Pages 108-108
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    2. Animal Models of Heart Failure

      • José Marín-García
      Pages 109-127

  6. Signaling, Stress and Cellular Changes in Heart Failure

    1. Front Matter

      Pages 130-130
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    2. Signaling Cascades in Heart Failure: From Cardiomyocytes Growth and Survival to Mitochondrial Signaling Pathways

      • José Marín-García
      Pages 131-160

    3. Cyclic Nucleotides Signaling (Second Messengers) and Control of Myocardial Function: Effects of Heart Failure

      • José Marín-García
      Pages 161-169

    4. Calcium Signaling: Receptors, Effectors, and Other Signaling Pathways

      • José Marín-García
      Pages 171-194

    5. Oxidative Stress and Heart Failure

      • José Marín-García
      Pages 195-211

    6. Cardiac Remodeling and Cell Death in Heart Failure

      • José Marín-García
      Pages 213-231

  7. Peripheral Changes and Co-morbid Conditions in Heart Failure

    1. Front Matter

      Pages 234-234
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    2. Heart Failure and Changes at the Periphery: Vascular, Inflammation, Neurohormonal, and Renal Systems

      • José Marín-García
      Pages 235-255

    3. Comorbidities in Heart Failure

      • José Marín-García
      Pages 257-270
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Keywords

About this book

Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.

Reviews

From the reviews:

“A clear and comprehensive review is desperately needed to lessen the time readers spend searching the Internet or rummaging through massive numbers of clinical trials. … the text still can appeal to any health science student, physician-in-training, practicing physician, and of course, cardiologist. In fact, this text is strongly recommended for cardiologists pursuing additional training in cardiac transplantation and care of advanced heart failure. … This book will serve as a useful reference and could become a powerful tool for cardiology … .” (Joseph Sam Owen, Journal of the American Medical Association, February, 2011)

“This book tackles a broad array of topics in heart failure in an organized manner. … most useful to specialists in heart failure, especially those with an interest in molecular and cell biology research, or those interested in translating basic science research into clinical investigations. The book will be of interest to cardiologists in training as well as adult and pediatric cardiologists. … It is unique as it adds gene expression and how it may play a role in the heart failure disease process.” (Joaquin Crespo, Doody’s Review Service, September, 2010)

Authors and Affiliations

  • Neuromuscular Institute, Molecular Cardiology &, Highland Park, USA

    José Marín-García

Bibliographic Information

  • Book Title: Heart Failure

  • Book Subtitle: Bench to Bedside

  • Authors: José Marín-García

  • Series Title: Contemporary Cardiology

  • DOI: https://doi.org/10.1007/978-1-60761-147-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2010

  • Hardcover ISBN: 978-1-60761-146-2Published: 29 June 2010

  • Softcover ISBN: 978-1-61779-693-7Published: 07 September 2012

  • eBook ISBN: 978-1-60761-147-9Published: 23 June 2010

  • Series ISSN: 2196-8969

  • Series E-ISSN: 2196-8977

  • Edition Number: 1

  • Number of Pages: XI, 470

  • Number of Illustrations: 14 b/w illustrations, 71 illustrations in colour

  • Topics: Cardiology, Angiology, Internal Medicine

  • Industry Sectors: Biotechnology, Engineering, Finance, Business & Banking, Health & Hospitals, Pharma

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