Antimicrobial Drug Resistance

1. Front Matter

   Pages i-xxvi

   PDF

2. General Overview

   1. History of Drug-Resistant Microbes

      • George A. Jacoby

      Pages 3-7

   2. Evolutionary Biology of Drug Resistance

      • Fernando Baquero, Rafael Cantón

      Pages 9-32

   3. Pharmacology of Drug Resistance

      • G. L. Drusano

      Pages 33-42

   4. Antimicrobial Resistance Versus the Discovery and Development of New Antimicrobials

      • David M. Shlaes, Steven J. Projan

      Pages 43-50

3. General Mechanisms of Drug Resistance

   1. Genetic Mechanisms of Transfer of Drug Resistance

      • Paul H. Roy

      Pages 53-64

   2. Mutations as a Basis of Antimicrobial Resistance

      • Maja Babic, Robert A. Bonomo

      Pages 65-74

   3. Target-Mediated Antibacterial Resistance

      • Louis B. Rice

      Pages 75-80

   4. Biochemical Logic of Antibiotic Inactivation and Modification

      • Vanessa D'Costa, Gerard D. Wright

      Pages 81-95

   5. Antibiotic Resistance Due to Reduced Uptake

      • Joseph B. McPhee, Sandeep Tamber, Michelle D. Brazas, Shawn Lewenza, Robert E. W. Hancock

      Pages 97-110

   6. Transport Mechanisms of Resistance to Drugs and Toxic Metals

      • Adrian R. Walmsley, Barry P. Rosen

      Pages 111-120

   7. The Functional Resistance of Bacterial Biofilms

      • Christoph A. Fux, Paul Stoodley, Mark Shirtliff, J. William Costerton

      Pages 121-131

4. Bacterial Drug Resistance – Mechanisms

   1. The Importance of β-Lactamases to the Development of New β-Lactams

      • Karen Bush

      Pages 135-144

   2. Penicillin-Binding Proteins and β-Lactam Resistance

      • André Zapun, Pauline Macheboeuf, Thierry Vernet

      Pages 145-170

   3. Aminoglycosides: Mechanisms of Action and Resistance

      • Maria L. Magalhães, John S. Blanchard

      Pages 171-181

   4. Tetracycline and Chloramphenicol Resistance Mechanisms

      • Marilyn C. Roberts, Stefan Schwarz

      Pages 183-193

   5. Fluoroquinolone Resistance in Bacteria

      • Varsha V. Moudgal, Glenn W. Kaatz

      Pages 195-205

   6. Plasmid-Mediated Quinolone Resistance

      • George A. Jacoby

      Pages 207-210

   7. Macrolides and Lincosamides

      • Annie Canu, Roland Leclercq

      Pages 211-221

   8. Mechanism of Resistance in Metronidazole

      • Abhay Dhand, David R. Snydman

      Pages 223-227

This ? rst edition of Antimicrobial Drug Resistance grew out of a desire by the editors and authors to have a comprehensive resource of information on antimicrobial drug resistance that encompassed the current information available for bacteria, fungi, protozoa and viruses. We believe that this information will be of value to clinicians, epidemiologists, microbiologists, virologists, parasitologists, public health authorities, medical students and fellows in training. We have endeavored to provide this information in a style which would be accessible to the broad community of persons who are concerned with the impact of drug resistance in our cl- ics and across the broader global communities. Antimicrobial Drug Resistance is divided into Volume 1 which has sections covering a general overview of drug resistance and mechanisms of drug resistance ? rst for classes of drugs and then by individual microbial agents including bacteria, fungi, protozoa and viruses. Volume 2 addresses clinical, epidemiologic and public health aspects of drug resistance along with an overview of the conduct and interpretation of speci? c drug resistance assays. Together, these two volumes offer a comprehensive source of information on drug resistance issues by the experts in each topic.

• Drug
• HIV
• Handbook
• Hepatitis
• Malaria
• Mayers
• Resistance
• Schistosomiasis
• Virus
• antibiotics
• antimicrobial
• antimicrobial resistance
• antiviral drug
• bacteria
• epidemiological
• infectious diseases

From the reviews: “This weighty tome … provides a series of reviews by internationally respected authors, including Drs Baquero, Bush, LeClercq, Jacoby and many more. … Overall, a worthwhile reference work for institutional libraries and for scientists with broad interests in the field of resistance.” (David Livermore, Microbiology Today, January, 2010)

• Executive Vice President & Chief Medical Offi cer, Idenix Pharmaceuticals, Cambridge, USA

  Douglas L. Mayers