Cardiac Repolarization

Bridging Basic and Clinical Science

  • Ihor Gussak
  • Charles Antzelevitch
  • Stephen C. Hammill
  • Win-Kuang Shen
  • Preben Bjerregaard

Part of the Contemporary Cardiology book series (CONCARD)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Thorsten Lewalter, Berndt Lüderitz
      Pages 7-21
  3. Basic Electrophysiology, Pharmacology, and Molecular Biology of Ventricular Repolarization

    1. Front Matter
      Pages 23-23
    2. Charles Antzelevitch, Andrew C. Zygmunt, Robert Dumaine
      Pages 63-89
    3. Charles Antzelevitch, Andrew C. Zygmunt, Jeffrey Fish, Guillermo Perez, Fabiana Scornik
      Pages 91-110
    4. Charles Antzelevitch, Vladislav V. Nesterenko
      Pages 111-126
    5. Antonis A. Armoundas, Gordon F. Tomaselli
      Pages 127-152
    6. André G. Kléber, Michiel J. Janse
      Pages 153-167
    7. Carlo Napolitano, Silvia G. Priori
      Pages 169-185
    8. Connie R. Bezzina, Arthur A. M. Wilde
      Pages 187-200
    9. Charles Antzelevitch, Alexander Burashnikov, Jose M. Di Diego
      Pages 201-251
  4. Clinical Physiology and Pathophysiology of Ventricular Repolarization: Theory and Practice

    1. Front Matter
      Pages 253-253
    2. Jan Nĕmec, Stephen C. Hammill, Win-Kuang Shen
      Pages 255-289
    3. Philip T. Sager
      Pages 291-310
    4. Wojciech Zareba, Arthur J. Moss
      Pages 311-328
    5. Philippe Coumel, Pierre Maison-Blanche
      Pages 329-350
    6. Morton F. Arnsdorf
      Pages 351-386

About this book

Introduction

The past decade has seen an explosion of knowledge and radical changes in our understanding of ventricular repolarization as an integral part of the cardiac electrophysiologic matrix. Cardiac Repolarization: Bridging Basic and Clinical Science comprehensively reviews all the latest developments in cardiac electrophysiology, focusing on both clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions, among them early repolarization and short QT interval, Brugada syndrome, long QT syndrome, and sudden infant death syndrome. Chapters delineate objectives and key points, and include established and evidence-based knowledge, current perspectives, areas of controversy, and recommendations for future investigations.
Comprehensive and clinically oriented, Cardiac Repolarization: Bridging Basic and Clinical Science surveys the major research discoveries that have recently transformed our understanding of cardiac electrophysiology and spells out in full detail their clinical implications for the diagnosis and treatment of patients with malignant electrical instability of the heart.

Keywords

drugs electrocardiogram (ECG) electrophysiology heart physiology

Editors and affiliations

  • Ihor Gussak
    • 1
  • Charles Antzelevitch
    • 2
  • Stephen C. Hammill
    • 3
  • Win-Kuang Shen
    • 3
  • Preben Bjerregaard
    • 4
  1. 1.eResearch Technology Inc.BridgewaterUSA
  2. 2.Masonic Medical Research LaboratoryUticaUSA
  3. 3.Mayo ClinicRochesterUSA
  4. 4.St. Louis University Health Sciences CenterSt. LouisUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-362-0
  • Copyright Information Springer Science+Business Media New York 2003
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-61737-336-7
  • Online ISBN 978-1-59259-362-0
  • Series Print ISSN 2196-8969
  • Series Online ISSN 2196-8977
  • About this book
Industry Sectors
Biotechnology
Pharma