Cardiac Repolarization

1. Front Matter

   Pages i-xvii

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2. Introduction

   1. Front Matter

      Pages 1-1

      PDF

   2. Ventricular Repolarization and the Identification of the Sudden Death Candidate

      • Hein J. Wellens, Douglas P. Zipes

      Pages 3-6

   3. Historical Milestones of Electrical Signal Recording and Analysis

      • Thorsten Lewalter, Berndt Lüderitz

      Pages 7-21

3. Basic Electrophysiology, Pharmacology, and Molecular Biology of Ventricular Repolarization

   1. Front Matter

      Pages 23-23

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   2. Physiology and Molecular Biology of Ion Channels Contributing to Ventricular Repolarization

      • Jeanne M. Nerbonne, Robert S. Kass

      Pages 25-62

   3. Electrophysiology and Pharmacology of Ventricular Repolarization

      • Charles Antzelevitch, Andrew C. Zygmunt, Robert Dumaine

      Pages 63-89

   4. How Do We Measure Repolarization Inside the Heart?

      • Charles Antzelevitch, Andrew C. Zygmunt, Jeffrey Fish, Guillermo Perez, Fabiana Scornik

      Pages 91-110

   5. Contribution of Electrical Heterogeneity of Repolarization to the ECG

      • Charles Antzelevitch, Vladislav V. Nesterenko

      Pages 111-126

   6. Electrical and Structural Remodeling of the Ventricular Myocardium in Disease

      • Antonis A. Armoundas, Gordon F. Tomaselli

      Pages 127-152

   7. Ischemia-Related Changes in Repolarization

      • André G. Kléber, Michiel J. Janse

      Pages 153-167

   8. The Long QT Syndrome

      • Carlo Napolitano, Silvia G. Priori

      Pages 169-185

   9. Ion Channel Disease as a Cause of the Brugada Syndrome

      • Connie R. Bezzina, Arthur A. M. Wilde

      Pages 187-200

   10. Cellular and Ionic Mechanisms Underlying Arrhythmogenesis

       • Charles Antzelevitch, Alexander Burashnikov, Jose M. Di Diego

       Pages 201-251

4. Clinical Physiology and Pathophysiology of Ventricular Repolarization: Theory and Practice

   1. Front Matter

      Pages 253-253

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   2. Evaluation of Ventricular Repolarization

      • Jan Nĕmec, Stephen C. Hammill, Win-Kuang Shen

      Pages 255-289

   3. Human Cardiac Repolarization

      • Philip T. Sager

      Pages 291-310

   4. QT Interval and Its Drug-Induced Prolongation

      • Wojciech Zareba, Arthur J. Moss

      Pages 311-328

   5. Neuro-Mediated Repolarization Abnormalities

      • Philippe Coumel, Pierre Maison-Blanche

      Pages 329-350

   6. The Electrophysiologic Matrix

      • Morton F. Arnsdorf

      Pages 351-386

A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.

• drugs
• electrocardiogram (ECG)
• electrophysiology
• heart
• physiology

"This comprehensive survey of the latest research and clinical findings in ventricular repolarization will certainly help to bridge the gap between basic and clinical science." - Acta Cardiologica

• eResearch Technology Inc., Bridgewater, USA

  Ihor Gussak

• Masonic Medical Research Laboratory, Utica, USA

  Charles Antzelevitch

• Mayo Clinic, Rochester, USA

  Stephen C. Hammill, Win-Kuang Shen

• St. Louis University Health Sciences Center, St. Louis, USA

  Preben Bjerregaard

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