© 2003

Dietary Supplements

Toxicology and Clinical Pharmacology

  • Melanie Johns Cupp
  • Timothy S. Tracy

Part of the Forensic Science and Medicine book series (FSM)

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Legal/Regulatory Aspects of Dietary Supplements

    1. Front Matter
      Pages 1-1
    2. Melanie Johns Cupp
      Pages 3-13
  3. Monographs

    1. Front Matter
      Pages 15-15
    2. Jason L. Duncan, Melanie Johns Cupp, Timothy S. Tracy
      Pages 17-32
    3. Kimberly Novak, Melanie Johns Cupp, Timothy S. Tracy
      Pages 33-39
    4. Aleshia R. Haslacker, Melanie Johns Cupp, Timothy S. Tracy
      Pages 41-52
    5. Melanie Johns Cupp, Timothy S. Tracy
      Pages 53-85
    6. Melanie Johns Cupp, Timothy S. Tracy
      Pages 87-90
    7. Nancy Romanchak, Melanie Johns Cupp, Timothy S. Tracy
      Pages 91-121
    8. John Edward Pope, Melanie Johns Cupp, Timothy S. Tracy
      Pages 123-147
    9. Melanie Johns Cupp, Timothy S. Tracy
      Pages 149-160
    10. Laura Martin, Melanie Johns Cupp, Timothy S. Tracy
      Pages 161-172
    11. Betsy Meredith, Melanie Johns Cupp, Timothy S. Tracy
      Pages 173-195
    12. Thomas A. Chase, Melanie Johns Cupp, Timothy S. Tracy
      Pages 197-207
    13. Melanie Johns Cupp, Timothy S. Tracy
      Pages 209-243
    14. Arthur I. Jacknowitz, Timothy S. Tracy
      Pages 245-252
    15. Ona Dingess, Melanie Johns Cupp, Timothy S. Tracy
      Pages 253-266
    16. Kerry Bowers, Melanie Johns Cupp, Timothy S. Tracy
      Pages 267-275
    17. Ann Sullivan, Melanie Johns Cupp, Timothy S. Tracy
      Pages 277-295

About this book


While sales of dietary supplements have skyrocketed in recent years, information about their safety and efficacy in humans is generally sparse in comparison with what is available for prescription drugs. Dietary Supplements: Toxicology and Clinical Pharmacology presents, in both comprehensive and summary formats, a wealth of objective information for a selection of significant nonherbal dietary supplements. The supplements detailed were chosen for their popularity, toxicity, and the quantity and quality of information available, and include such well-known agents as DHEA,
androstenedione and other over-the-counter steroids, coenzyme Q10, fish oil, glucosamine and chondroitin, chitosan, chromium picolinate, creatine, vanadyl sulfate, SAMe, and melatonin. Additional coverage is given to colloidal silver, shark cartilage, germanium, red yeast rice extract, l-tryptophan, N,N-dimethylglycine, GHB and GBL, huperzine, hydrazine, methylsulfonylmethane, and pyruvate. Each monograph discusses the history of the compound; its chemical structure; its current and promoted uses, sources, and chemical composition; and its toxicity, pharmacokinetics, and physiological role. Also presented are case reports of their adverse effects and interactions, as well as information on their reproductive effects, chemical and biofluid analysis, and regulatory status. Each chapter is based on original studies published in reputable peer-reviewed journals, as well as on meta-analyses, systematic reviews, or other high-quality assessments by recognized experts.
Authoritative and objective, Dietary Supplements: Toxicology and Clinical Pharmacology offers physicians, pharmacologists, pharmacists, toxicologists, and medical examiners a treasure trove of uncommon-but reliable-scientific and clinical information on the toxicity and usefulness of today's leading nonherbal dietary supplements.


AIDS Diabetes HIV body composition cancer chromium depression kinetics lipide metabolism pharmacokinetics steroids toxicity toxicology

Editors and affiliations

  • Melanie Johns Cupp
    • 1
  • Timothy S. Tracy
    • 1
  1. 1.West Virginia UniversityMorgantownUSA

Bibliographic information

  • Book Title Dietary Supplements
  • Book Subtitle Toxicology and Clinical Pharmacology
  • Editors Melanie Johns Cupp
    Timothy S. Tracy
  • Series Title Forensic Science and Medicine
  • DOI
  • Copyright Information Springer Science+Business Media New York 2003
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-1-58829-014-4
  • Softcover ISBN 978-1-4684-9726-7
  • eBook ISBN 978-1-59259-303-3
  • Edition Number 1
  • Number of Pages XXIII, 410
  • Number of Illustrations 5 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
Industry Sectors
Chemical Manufacturing
Health & Hospitals
Pharmacology & Toxicology
Consumer Packaged Goods


"The book is nonjudgmental and backs up its assertions with pertinent references and provides data on both positive and negative aspects of each supplement. The summary chart at the end of the book provides a quick reference for the reader.This is a useful and enlightening book. It is a nice alternative to the multiple other options on supplements as it uses reliable sources and is scientifically based. Some of the data, such as interactions and pharmacokinetics, is difficult to find without substantial research. It has been nicely collected in this one book.This book is intended for practicing healthcare clinicians who have patients using these supplements, particularly internists, family practitioners, and emergency physicians. It also has utility for exercise physiologists and other specialists whose patients may be using these supplements for particular ailments or aims. Forensic physicians and researchers will find the information on pharmacokinetics, biofluid analysis and interactions quite useful.
"-Doody's Health Sciences Book Review Journal

"...fills a niche that needed filling and offers a large amount of valuable material that is sure to become increasingly important to the practice of forensic science in the not too distant future." - Canadian Society of Forensic Science Journal