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Computational Stem Cell Biology

Methods and Protocols

Editors:

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1975)

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Table of contents (20 protocols)

  1. Front Matter

    Pages i-xi
  2. Modeling

    1. Front Matter

      Pages 1-1
    2. Modeling Cellular Differentiation and Reprogramming with Gene Regulatory Networks

      • András Hartmann, Srikanth Ravichandran, Antonio del Sol
      Pages 37-51
    3. Computational Tools for Quantifying Concordance in Single-Cell Fate

      • J. A. Cornwell, R. E. Nordon
      Pages 131-156
    4. Quantitative Modelling of the Waddington Epigenetic Landscape

      • Atefeh Taherian Fard, Mark A. Ragan
      Pages 157-171
  3. Single Cell Approaches

    1. Front Matter

      Pages 191-191
    2. Trajectory Algorithms to Infer Stem Cell Fate Decisions

      • Edroaldo Lummertz da Rocha, Mohan Malleshaiah
      Pages 193-209
    3. Gene Regulatory Networks from Single Cell Data for Exploring Cell Fate Decisions

      • Thalia E. Chan, Michael P. H. Stumpf, Ann C. Babtie
      Pages 211-238
    4. Reconstructing Gene Regulatory Networks That Control Hematopoietic Commitment

      • Fiona K. Hamey, Berthold Göttgens
      Pages 239-249
  4. Metabolism

    1. Front Matter

      Pages 303-303
    2. Dynamic Network Modeling of Stem Cell Metabolism

      • Fangzhou Shen, Camden Cheek, Sriram Chandrasekaran
      Pages 305-320
    3. Metabolomics in Stem Cell Biology Research

      • Zhen Sun, Jing Zhao, Hua Yu, Chenyang Zhang, Hu Li, Zhongda Zeng et al.
      Pages 321-330
  5. Assessing and Improving Cell Fate Engineering

    1. Front Matter

      Pages 331-331

About this book

This volume details methods and protocols to further the study of stem cells within the computational stem cell biology (CSCB) field. Chapters are divided into four sections covering the theory and practice of modeling of stem cell behavior, analyzing single cell genome-scale measurements, reconstructing gene regulatory networks, and metabolomics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.



Authoritative and cutting-edge, Computational Stem Cell Biology: Methods and Protocols will be an invaluable guide to researchers as they explore stem cells from the perspective of computational biology.


Editors and Affiliations

  • Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USA

    Patrick Cahan

Bibliographic Information

  • Book Title: Computational Stem Cell Biology

  • Book Subtitle: Methods and Protocols

  • Editors: Patrick Cahan

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-9224-9

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2019

  • Hardcover ISBN: 978-1-4939-9223-2Published: 07 May 2019

  • Softcover ISBN: 978-1-4939-9226-3Published: 28 October 2020

  • eBook ISBN: 978-1-4939-9224-9Published: 06 May 2019

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 456

  • Number of Illustrations: 12 b/w illustrations, 95 illustrations in colour

  • Topics: Stem Cells, Computer Appl. in Life Sciences, Computational Biology/Bioinformatics

  • Industry Sectors: Biotechnology

Buy it now

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access