Skip to main content
  • Book
  • © 2018

Polycystic Kidney Disease

Translating Mechanisms into Therapy

  • Provides a comprehensive review of PKD mutations, pathophysiologic mechanisms of PKD, renal and extrarenal manifestations of PKD, clinical trials and emerging therapies in PKD, and appropriate management of patients with PKD
  • Written by top professionals in the field
  • Well-illustrated resource serves both clinician and researcher

Buy it now

Buying options

eBook USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (15 chapters)

  1. Front Matter

    Pages i-xiii
  2. PKD: Genes and Proteins

    1. Front Matter

      Pages 1-1
    2. Bardet-Biedl Syndrome

      • Yangfan P. Liu, Nicholas Katsanis
      Pages 27-50
  3. PKD: Mechanisms of Disease

    1. Front Matter

      Pages 67-67
    2. Aberrant Cellular Pathways in PKD

      • Alison Grazioli, Patricia Outeda, Terry Watnick
      Pages 69-86
    3. Cilia and Polycystic Kidney Disease

      • Dawn E. Landis, Scott J. Henke, Bradley K. Yoder
      Pages 87-110
    4. The Role of Inflammation and Fibrosis in Cystic Kidney Disease

      • James C. Harms, Cheng Jack Song, Michal Mrug
      Pages 111-129
  4. ADPKD: Clinical Features

    1. Front Matter

      Pages 131-131
    2. Imaging-Based Diagnosis of Autosomal Dominant Polycystic Kidney Disease

      • Young-Hwan Hwang, Moumita Barua, Anna McNaught, Korosh Khalili, York Pei
      Pages 133-142
    3. Renal Complications: Pain, Infection, and Nephrolithiasis

      • Cristian Riella, Peter G. Czarnecki, Theodore I. Steinman
      Pages 155-169
  5. ADPKD: Clinical Trials and Emerging Therapies

    1. Front Matter

      Pages 207-207
    2. Vasopressin Receptor Antagonism in PKD

      • Maria V. Irazabal, Vicente E. Torres
      Pages 219-227
    3. Management of ADPKD Today

      • Ronald D. Perrone, Osama W. Amro
      Pages 243-262

About this book

This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease.  The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms.  This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients.  The final section covers current clinical trials and emerging therapies in PKD.  Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.

Editors and Affiliations

  • John Gammill Professor in Polycystic Kidney Disease, Chief, Section of Nephrology and Hypertension, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA

    Benjamin D. Cowley, Jr.

  • Federal Express Chair of Excellence, Chief, Division of Nephrology, Department of Pediatrics, Director, Tuberous Sclerosis Center of Excellence at Le Bonheur Children’s Hospital, Medical Director, Nephrology St. Jude Children’s Research Hospital, University of Tennessee Health Science Center, Children’s Foundation Research Center, Memphis, USA

    John J. Bissler

About the editors

John J. Bissler, MD

Federal Express Chair of Excellence, Professor and Chief, Division of Nephrology, Department of Pediatrics, Director of the Tuberous Sclerosis Center of Excellence at Le Bonheur Children’s Hospital, Medical Director of Nephrology, St. Jude Children's Research Hospital, University of Tennessee Health Science Center

University of Tennessee Health Science Center

Children’s Foundation Research Center

Memphis, TN 


Benjamin D. Cowley, Jr., M.D., F.A.C.P., F.A.S.N.

Professor of Medicine

Chief, Nephrology & Hypertension

John Gammill Professor in Polycystic Kidney Disease

University of Oklahoma Health Sciences Center

Oklahoma City, OK


Bibliographic Information

  • Book Title: Polycystic Kidney Disease

  • Book Subtitle: Translating Mechanisms into Therapy

  • Editors: Benjamin D. Cowley, Jr., John J. Bissler

  • DOI: https://doi.org/10.1007/978-1-4939-7784-0

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018

  • Hardcover ISBN: 978-1-4939-7782-6Published: 25 May 2018

  • Softcover ISBN: 978-1-4939-9284-3Published: 25 July 2019

  • eBook ISBN: 978-1-4939-7784-0Published: 24 May 2018

  • Edition Number: 1

  • Number of Pages: XIII, 273

  • Number of Illustrations: 20 b/w illustrations, 42 illustrations in colour

  • Topics: Nephrology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

Buy it now

Buying options

eBook USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access