Integrin Targeting Systems for Tumor Diagnosis and Therapy

1. Front Matter

   Pages i-xi

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2. Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnetic Iron Oxides

   • Fabienne Danhier, Pierre Danhier, Nathalie Schleich, Chrystelle Po, Sophie Laurent, Pierre Sibret et al.

   Pages 1-17

3. Fabrication of cRGD-Conjugated Dual-Responsive Micelles to Target αvβ5 Integrin-Overexpressed Cancer

   • Huacheng He, Remant Bahadur K.C., Peisheng Xu

   Pages 19-34

4. Copper-Free Click Chemistry Modification of Nanovectors for Integrin-Targeted Cancer Therapy

   • Chang-Fang Wang, Hélder A. Santos

   Pages 35-49

5. Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal Doxorubicin Modified with Different cRGD Peptides

   • Mohamadreza Amin, Mahmoud Reza Jaafari

   Pages 51-68

6. Preparation of Heterobivalent and Multivalent Radiopharmaceuticals to Target Tumors Over-Expressing Integrins

   • Guillermina Ferro-Flores, Blanca Ocampo-García, Clara Santos-Cuevas, Nallely Jiménez-Mancilla, Myrna Luna-Gutiérrez, Flor de M. Ramírez et al.

   Pages 69-92

7. 177Lu-Labeled RGD-BBN Peptide for Targeting Prostate Cancer

   • Lei Jiang, Zhen Cheng

   Pages 93-98

8. Integrin-Mediated Targeting of Liposomally Bound siRNAs to Tumor Vasculatures

   • Poulami Majumder, Arabinda Chaudhuri

   Pages 99-122

9. Integrin α_vβ₃-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide

   • Hao Hong, Weibo Cai

   Pages 123-134

10. Integrin Targeting Using RGD-Based Peptide Amphiphiles

    • Poonam Saraf, Xiaoling Li, Bhaskara Jasti

    Pages 135-155

11. Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting

    • Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, T. Srinivasa Reddy, Ayan Kumar Barui, Chitta Ranjan Patra et al.

    Pages 157-168

12. Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds via Integrin Receptors

    • Jitka Neburkova, Miroslav Hajek, Ivan Rehor, Jiri Schimer, Frantisek Sedlak, Jan Stursa et al.

    Pages 169-189

13. NIR Imaging-Guided Photothermal Therapy by cRGD-Conjugated Solid Lipid Nanoparticles Encapsulating IR-780

    • Ye Kuang, Kunchi Zhang, Min Liu, Renjun Pei

    Pages 191-206

14. Synergistic Active Targeting to B16F10 Tumors by αvβ3/CD44-Targeted Nanoparticles Loaded with Docetaxel

    • Sanjun Shi

    Pages 207-223

15. Back Matter

    Pages 225-226

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This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory. 
Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research.

• Multiple organ diseases
• Structural analysis
• Biomarkers
• Drug delivery
• Cancer research
• Integrin imaging

• Department of Gastroenterology and Hepatology, UniversitätsSpital Zürich, Zürich, Switzerland

  Eleonora Patsenker

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