Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases

  • Barbara Stefanska
  • David J. MacEwan

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Sophie Petropoulos, David Cheishvili, Moshe Szyf
    Pages 1-15
  3. David Cheishvili, Sophie Petropoulos, Steffan Christiansen, Moshe Szyf
    Pages 33-50
  4. Sushuma Yarlagadda, Anusha Thota, Ruchi Bansal, Jason Kwon, Murray Korc, Janaiah Kota
    Pages 97-113
  5. Marlene Remely, Heidrun Karlic, Irene Rebhan, Martina Greunz, Alexander G. Haslberger
    Pages 115-134
  6. David J. MacEwan, Niraj M. Shah, Daniel J. Antoine
    Pages 155-167
  7. Borut Peterlin, Ales Maver, Vidmar Lovro, Luca Lovrečić
    Pages 169-192
  8. Back Matter
    Pages 193-197

About this book

Introduction

This practical collection examines methodologies originating from the benefits of genome-wide approaches to studying epigenetics, which has opened the emerging field of epigenomics. Focusing on the areas of cancer, inflammatory and autoimmune disorders, chapters discuss three main components of the epigenome and their role in the regulation of gene expression and present a detailed method section specific to studying each component, including data analyses, troubleshooting, and feasibility in different experimental settings. The main topics are high-throughput and targeted methods for DNA methylation analysis, nucleosome position mapping, studying epigenetic effects of gut microbiota, optical imaging for detection of epigenetic aberrations in living cells, methods for microRNA, and histone code profiling. Written for the Methods in Pharmacology and Toxicologyseries, the book includes the kind of detail and implementation advice to encourage success in the lab. 
Authoritative and easily applicable, Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases aims to provide pharmacologists, molecular biologists, bioinformaticians, and toxicologists with a vital background on epigenetics and state-of-the-art techniques in epigenomics.

Keywords

DNA methylation Histone covalent modifications Non-coding RNA mechanisms Epigenomics Nucleosome position mapping Optical imaging Epigenetic aberrations

Editors and affiliations

  • Barbara Stefanska
    • 1
  • David J. MacEwan
    • 2
  1. 1.Department of Nutrition SciencePurdue UniversityWest LafayetteUSA
  2. 2.Department of Molecular and Clinical PharmacologyInstitute of Translational Medicine University of LiverpoolLiverpoolUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-6743-8
  • Copyright Information Springer Science+Business Media LLC 2017
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-6741-4
  • Online ISBN 978-1-4939-6743-8
  • Series Print ISSN 1557-2153
  • Series Online ISSN 1940-6053
  • About this book
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