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Oncogene-Induced Senescence

Methods and Protocols

  • Book
  • © 2017


  • Includes cutting-edge methods and protocols for the study of oncogene-induced senescence
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material:

Part of the book series: Methods in Molecular Biology (MIMB, volume 1534)

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About this book

This book offers in a single volume a unique collection of the state-of the-art experimental procedures utilized for the induction, detection, and modeling of this complex cellular program of oncogene-induced senescence. The book encompasses protocols for studying this multi-step program in human specimens and a variety of experimental models including cultured mammalian cells, laboratory mice, and Drosophila melanogaster, as well as offering a description of high throughput approaches. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Oncogene-Induced Senescence: Methods and Protocols represents a valuable asset for a wide audience of medical oncologists and researchers in the fields of oncology, molecular and cellular biology, biochemistry, and animal development.

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Table of contents (20 protocols)

Editors and Affiliations

  • Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, USA

    Mikhail A. Nikiforov

Bibliographic Information

  • Book Title: Oncogene-Induced Senescence

  • Book Subtitle: Methods and Protocols

  • Editors: Mikhail A. Nikiforov

  • Series Title: Methods in Molecular Biology

  • DOI:

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2017

  • Hardcover ISBN: 978-1-4939-6668-4Published: 03 November 2016

  • Softcover ISBN: 978-1-4939-8267-7Published: 27 June 2018

  • eBook ISBN: 978-1-4939-6670-7Published: 03 November 2016

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 220

  • Number of Illustrations: 9 b/w illustrations, 23 illustrations in colour

  • Topics: Cancer Research

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma

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