Skip to main content
  • Book
  • © 2017

Systems Genetics

Methods and Protocols

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1488)

Buy it now

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (29 protocols)

  1. Systems Genetics Use Cases: Mapping and Combining Multiple Phenotypic Traits

    1. Genomic Control of Retinal Cell Number: Challenges, Protocol, and Results

      • Patrick W. Keeley, Irene E. Whitney, Benjamin E. Reese
      Pages 365-390
    2. Systems Genetics Analysis to Identify the Genetic Modulation of a Glaucoma-Associated Gene

      • Sumana R. Chintalapudi, Monica M. Jablonski
      Pages 391-417
    3. Complex Genetics of Cardiovascular Traits in Mice: F2-Mapping of QTLs and Their Underlying Genes

      • Svitlana Podliesna, Connie R. Bezzina, Elisabeth M. Lodder
      Pages 431-454
    4. Systems Genetics of Liver Fibrosis

      • Rabea A. Hall, Frank Lammert
      Pages 455-466
    5. Systems Genetics of Obesity

      • Gudrun A. Brockmann, Danny Arends, Sebastian Heise, Ayca Dogan
      Pages 481-497
    6. Complex Genetics of Behavior: BXDs in the Automated Home-Cage

      • Maarten Loos, Matthijs Verhage, Sabine Spijker, August B. Smit
      Pages 519-530
    7. Dissection of Host Susceptibility to Bacterial Infections and Its Toxins

      • Aysar Nashef, Mahmoud Agbaria, Ariel Shusterman, Nicola Ivan Lorè, Alessandra Bragonzi, Ervin Wiess et al.
      Pages 551-578
  2. Back Matter

    Pages 607-609

About this book

This volume focuses on the use of system genetic methods and the use of murine models to study the role of gene variants and environmental factors on human health and disease—what is now often called personalized or precision health care. The protocols in this book will help readers analyze genetic causes of heritable variation across a wide range of systems and traits using rodent models. The chapters in this book are separated into three sections that cover: 1) resources for systems genetics; 2) tools for analysis and integration in systems genetics; and 3) systems genetics use cases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and tools, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.

Practical and thorough, Systems Genetics: Methods and Protocols is a valuable resource for anyone who is interested in this diverse field.

Editors and Affiliations

  • Department of Infection Genetics, Helmholtz Centre for Infection Research & University of Veterinary Medicine Hannover, Braunschweig, Germany

    Klaus Schughart

  • Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, USA

    Robert W. Williams

Bibliographic Information

  • Book Title: Systems Genetics

  • Book Subtitle: Methods and Protocols

  • Editors: Klaus Schughart, Robert W. Williams

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-6427-7

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2017

  • Hardcover ISBN: 978-1-4939-6425-3Published: 08 December 2016

  • Softcover ISBN: 978-1-4939-8196-0Published: 06 July 2018

  • eBook ISBN: 978-1-4939-6427-7Published: 08 December 2016

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIV, 609

  • Number of Illustrations: 27 b/w illustrations, 137 illustrations in colour

  • Topics: Human Genetics

  • Industry Sectors: Biotechnology, Pharma

Buy it now

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access