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  • Book
  • © 2016

Bacterial Therapy of Cancer

Methods and Protocols

  • Includes cutting-edge methods and protocols

  • Provides step-by-step detail essential for reproducible results

  • Contains key notes and implementation advice from the experts

  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1409)

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • ISBN: 978-1-4939-3515-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 119.99
Price excludes VAT (USA)
Hardcover Book USD 169.99
Price excludes VAT (USA)

This is a preview of subscription content, access via your institution.

Table of contents (15 protocols)

  1. Front Matter

    Pages i-xvi
  2. Microfluidic Device to Quantify the Behavior of Therapeutic Bacteria in Three-Dimensional Tumor Tissue

    • Emily L. Brackett, Charles A. Swofford, Neil S. Forbes
    Pages 35-48
  3. Tumor-Targeting Therapy Using Gene-Engineered Anaerobic-Nonpathogenic Bifidobacterium longum

    • Shun’ichiro Taniguchi, Yuko Shimatani, Minoru Fujimori
    Pages 49-60
  4. In Vivo Bioluminescence Imaging of Intratumoral Bacteria

    • Michelle Cronin, Ali R. Akin, Kevin P. Francis, Mark Tangney
    Pages 69-77
  5. Development of a Targeted Gene-Delivery System Using Escherichia coli

    • Chung-Jen Chiang, Chih-Hsiang Chang, Yun-Peng Chao, Ming-Ching Kao
    Pages 85-93
  6. Isolation and Analysis of Suppressor Mutations in Tumor-Targeted msbB Salmonella

    • K. Brooks Low, Sean R. Murray, John Pawelek, David Bermudes
    Pages 95-123
  7. Methods for Tumor Targeting with Salmonella typhimurium A1-R

    • Robert M. Hoffman, Ming Zhao
    Pages 143-164
  8. Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer

    • Robert M. Hoffman, Shuya Yano
    Pages 165-175
  9. Future of Bacterial Therapy of Cancer

    • Robert M. Hoffman
    Pages 177-184
  10. Back Matter

    Pages 185-186

About this book

This volume explores the evolution of bacterial cancer therapy and describes the modern techniques used in therapy today. The chapters in this book cover a broad range of topics such as the development of tumor-targeting Salmonella typhimurium A1-R, a microfluidic device for precise quantification of the interactions between tumor-targeting bacteria and tumor tissue, non-invasive in vivo imaging of bacteria-mediated cancer therapy using bio-luminescent bacteria, methods to achieve remote-control of therapeutic gene expression in tumor-targeting bacteria, and cell-cycle decoy of cancer cells resistant to cytotoxic drugs to drug sensitivity by S. typhimurium A1-R. This book concludes with a chapter on the future potential of bacterial therapy of cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Thorough and informative, Bacterial Therapy of Cancer: Methods and Protocols is a valuable resource for anyone who is interested in cancer and bacterial therapy.

Keywords

  • bacterial cancer therapy
  • tumor-targeting Salmonella
  • mouse tumor model
  • tumor tissue
  • drug delivery system
  • bio-luminescent bacteria
  • therapeutic expression

Editors and Affiliations

  • Department of Surgery, AntiCancer Inc, Univ of California – San Diego, San Diego, USA

    Robert M Hoffman

About the editor

Robert M. Hoffman, Ph.D. Professor of Surgery, University of California, San Diego President, AntiCancer, Inc. 7917 Ostrow Street San Diego, CA 92111 USA TEL: 1-858-654-2555 FAX: 1-858-268-4175 Email: all@anticancer.com

Bibliographic Information

  • Book Title: Bacterial Therapy of Cancer

  • Book Subtitle: Methods and Protocols

  • Editors: Robert M Hoffman

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-3515-4

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-3513-0

  • Softcover ISBN: 978-1-4939-8063-5

  • eBook ISBN: 978-1-4939-3515-4

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XVI, 186

  • Number of Illustrations: 10 b/w illustrations, 33 illustrations in colour

  • Topics: Cancer Biology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • ISBN: 978-1-4939-3515-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 119.99
Price excludes VAT (USA)
Hardcover Book USD 169.99
Price excludes VAT (USA)