Editors:
Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 1395)
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Table of contents (18 protocols)
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Front Matter
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Back Matter
About this book
This volume discusses the latest advancements and technologies used in cancer drug resistance research. Cancer Drug Resistance: Overviews and Methods contains chapters that cover topics such as: studying the mechanics of resistance to DNA damaging therapeutic drugs; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; the role of microRNAs in current pancreatic cancer treatment; and cancer exosomes as mediators of drug resistance or clinical and molecular methods in drug development and the use of bioinformatics in the management of cancer drug resistance data. Written in the highly successful Methods in Molecular Biology series format, chapters include overviews of the main issues in cancer drug resistance and the respective mechanisms, as well as introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Cancer Drug Resistance: Overviews and Methods, is a valuable resource to researchers, oncobiologists and clinical oncologists or anyone else who is interested in the study of cancer and its drug resistances.
Keywords
- cellular resistance
- multi-drug resistance (MDR)
- DNA
- chemotherapy
- adenosine5'-triphosphate (ATP)
- binding cassette (ABC) transporters
- microRNAs
- proteomics
Editors and Affiliations
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New University of Lisbon, Lisbon, Portugal
Jose Rueff, António Sebastião Rodrigues
Bibliographic Information
Book Title: Cancer Drug Resistance
Book Subtitle: Overviews and Methods
Editors: Jose Rueff, António Sebastião Rodrigues
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-4939-3347-1
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2016
Hardcover ISBN: 978-1-4939-3345-7Published: 25 February 2016
Softcover ISBN: 978-1-4939-8027-7Published: 20 March 2019
eBook ISBN: 978-1-4939-3347-1Published: 24 February 2016
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XIII, 314
Number of Illustrations: 10 b/w illustrations, 37 illustrations in colour
Topics: Pharmacology/Toxicology
Industry Sectors: Biotechnology, Chemical Manufacturing, Consumer Packaged Goods, Finance, Business & Banking, Health & Hospitals, Pharma