Overview
- Includes cutting-edge methods and protocols
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
Part of the book series: Neuromethods (NM, volume 105)
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Table of contents (15 protocols)
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Front Matter
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Analysis of Chromatin Remodeling
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Front Matter
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Analysis of Non-coding Genome
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Front Matter
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Analysis of Circadian Oscilations
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Front Matter
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Keywords
About this book
This volume presents state-of-the-art methods for reliable detection of epigenetic changes in the nervous system. Epigenetic Methods in Neuroscience Research guides readers through methods for the analyses of chromatin remodeling, transposable elements, non-coding RNAs, such as miRNAs, and circadian oscillations, including: analysis of DNA methylation in neuronal and glial cells or small tissue samples; sensitive method for quantification of alternative methylated forms of cytosines by liquid chromatography/mass spectrometry; affinity-based detection of modified cytosines by immunohistochemistry or methylated DNA immunoprecipitation; chromatin immunoprecipitation, or ChIP; miRNA high-throughput profiling and the in situ detection of miRNA subtle expression in the brain; analysis of genes with alternative 3’UTRs; and the cite-specific delivery of chromatin-modifying drugs. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.
Concise and easy-to-use, Epigenetic Methods in Neuroscience Research provides multidisciplinary epigenetic approach to study genome, and neural, plasticity that will help the reader to successfully address the challenges associated with neurodevelopmental, psychiatric, and neurodegenerative disorders.
Editors and Affiliations
Bibliographic Information
Book Title: Epigenetic Methods in Neuroscience Research
Editors: Nina Karpova
Series Title: Neuromethods
DOI: https://doi.org/10.1007/978-1-4939-2754-8
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2016
Hardcover ISBN: 978-1-4939-2753-1Published: 13 October 2015
Softcover ISBN: 978-1-4939-4941-0Published: 23 August 2016
eBook ISBN: 978-1-4939-2754-8Published: 12 October 2015
Series ISSN: 0893-2336
Series E-ISSN: 1940-6045
Edition Number: 1
Number of Pages: XII, 258
Number of Illustrations: 6 b/w illustrations, 37 illustrations in colour
Topics: Neurosciences
Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma