Biobetters

Protein Engineering to Approach the Curative

  • Amy Rosenberg
  • Barthélemy Demeule

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 19)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Therapeutic Enzymes

  3. Monoclonal Antibodies: Degradation Mechanisms and Potential Improvements

    1. Front Matter
      Pages 79-79
    2. Balakrishnan S. Moorthy, Bo Xie, Ehab M. Moussa, Lavanya K. Iyer, Saradha Chandrasekhar, Jainik P. Panchal et al.
      Pages 81-89
    3. Tudor Arvinte, Emilie Poirier, Caroline Palais
      Pages 91-104
    4. Balakrishnan S. Moorthy, Bo Xie, Ehab M. Moussa, Lavanya K. Iyer, Saradha Chandrasekhar, Jainik P. Panchal et al.
      Pages 105-135
  4. New Platforms

  5. Economic and Regulatory Considerations

    1. Front Matter
      Pages 313-313

About this book

Introduction

Over the last few decades, biopharmaceuticals have transformed many areas of healthcare and have given hope and extended the lives of many patients. Curative treatments, however, remain elusive in most cases. This book describes strategies to develop improved versions of biopharmaceuticals (“biobetters”) to bridge the gap between existing therapies and curative therapies. With an aim to stimulate research and development in a wide array of therapeutic areas, diverse topics are covered, including the following: tissue specific targeting of enzyme replacement therapies; the development of novel protein structures with the potential to improve upon critical attributes of current monoclonal antibodies; the modification of current monoclonal antibody designs to improve their in vivo stability; and finally, the economic and regulatory considerations for the development of biobetters.

Keywords

drug targeting immunogenicity monoclonal antibodies pharmacokinetics therapeutic enzymes

Editors and affiliations

  • Amy Rosenberg
    • 1
  • Barthélemy Demeule
    • 2
  1. 1.Centre for Drug Evaluation and Research, Food and Drug AdministrationDivision of Biotechnology Review and Research III, Office of Biotechnology ProductsSilver SpringUSA
  2. 2.Genentech, Inc.South San FranciscoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-2543-8
  • Copyright Information American Association of Pharmaceutical Scientists 2015
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4939-2542-1
  • Online ISBN 978-1-4939-2543-8
  • Series Print ISSN 2210-7371
  • Series Online ISSN 2210-738X
  • About this book
Industry Sectors
Chemical Manufacturing
Biotechnology
Consumer Packaged Goods
Pharma