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Mast Cells

Methods and Protocols

  • Michael R. Hughes
  • Kelly M. McNagny

Part of the Methods in Molecular Biology book series (MIMB, volume 1220)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Ontology, Phylogeny, and Tissue Distribution of Mast Cells

    1. Front Matter
      Pages 1-1
    2. Jack Ghably, Hana Saleh, Harsha Vyas, Emma Peiris, Niva Misra, Guha Krishnaswamy
      Pages 3-10
    3. Enrico Crivellato, Luciana Travan, Domenico Ribatti
      Pages 11-27
    4. Sahar I Da’as, Tugce B. Balci, Jason N. Berman
      Pages 29-57
    5. Gail M. Gauvreau, Judah A. Denburg
      Pages 59-68
    6. Mamiko Sakata-Yanagimoto, Shigeru Chiba
      Pages 79-89
  3. Mast Cells in Human Health and Disease

    1. Front Matter
      Pages 91-91
    2. Erin J. DeBruin, Matthew Gold, Bernard C. Lo, Kimberly Snyder, Alissa Cait, Nikola Lasic et al.
      Pages 93-119
    3. Joseph S. Janicki, Gregory L. Brower, Scott P. Levick
      Pages 121-139
    4. Geethani Bandara, Dean D. Metcalfe, Arnold S. Kirshenbaum
      Pages 155-162
    5. Axel Lorentz, Gernot Sellge, Stephan C. Bischoff
      Pages 163-177
    6. Ian D. Haidl, Jean S. Marshall
      Pages 179-201
  4. Molecular Mechanisms of Mast Cell Function

    1. Front Matter
      Pages 203-203
    2. Yuko Kawakami, Toshiaki Kawakami
      Pages 205-218
    3. Eon J. Rios, Janet Kalesnikoff
      Pages 239-255
    4. Christine Möller Westerberg, Maria Ekoff, Gunnar Nilsson
      Pages 257-267
    5. Alexander Geldman, Catherine J. Pallen
      Pages 269-286
    6. Steven Maltby, Maximilian Plank, Catherine Ptaschinski, Joerg Mattes, Paul S. Foster
      Pages 287-304
  5. Mast Cell Products and Mediators

    1. Front Matter
      Pages 305-305
    2. Madeleine Rådinger, Bettina M. Jensen, Emily Swindle, Alasdair M. Gilfillan
      Pages 307-323
    3. Fabio R. Melo, Sara Wernersson, Gunnar Pejler
      Pages 325-337
    4. Chris D. St. Laurent, Tae Chul Moon, A. Dean Befus
      Pages 339-345
    5. Roy Cohen, David A. Holowka, Barbara A. Baird
      Pages 347-363
    6. Glenn Cruse, Alasdair M. Gilfillan, Daniel Smrz
      Pages 365-379
    7. D. James Haddon, Justin A. Jarrell, Michael R. Hughes, Kimberly Snyder, Kelly M. McNagny, Michael G. Kattah et al.
      Pages 381-400
  6. Mouse Models of Disease to Study Mast Cell Function

    1. Front Matter
      Pages 401-401
    2. Katrin Peschke, Anne Dudeck, Anja Rabenhorst, Karin Hartmann, Axel Roers
      Pages 403-421
    3. Peter A. Nigrovic, Kichul Shin
      Pages 423-442
    4. Nichole R. Blatner, FuNien Tsai, Khashayarsha Khazaie
      Pages 443-460
    5. Victor C. de Vries, Isabelle Le Mercier, Elizabeth C. Nowak, Randolph J. Noelle
      Pages 461-486
    6. Renato C. Monteiro, Walid Beghdadi, Lydia Celia Madjene, Maguelonne Pons, Michel Peuchmaur, Ulrich Blank
      Pages 487-496
    7. Yuko Kawakami, Toshiaki Kawakami
      Pages 497-502
    8. Matthew Gold, David Marsolais, Marie-Renee Blanchet
      Pages 503-519
    9. Matthew Gold, Marie-Renee Blanchet
      Pages 521-527
  7. Back Matter
    Pages 529-540

About this book

Introduction

Mast Cells: Methods and Protocols, Second Edition expands upon the previous edition with current, detailed reviews that cover topics of interest to mast cell neophytes and cognoscenti alike.  With new chapters on methods for the enumeration of tissue mast cells and isolation of mature mast cells and mast cell progenitors from mammalian tissues, Danio rerio (zebrafish) model in the study of mast cell development and function, the functions of mast cells in human health and disease and methods for the isolation, methods for the investigation of the molecular mechanisms of mast cell activation and their effector functions, assays for the detection and analysis of mast cell secretory and cell surface phenotype and, mast cell activation state, and experimental mouse models of disease that have been deemed useful for the assessment of mast cell functions in the regulation of innate and adaptive immune response in cancer, tissue fibrosis, auto-inflammation and allergic disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Mast Cells: Methods and Protocols, Second Edition provides a sampler of useful methods and techniques in the further study of mast cell biology.

Keywords

allergic disease auto-inflammation cancer cell surface phenotype developmental ontology disease enumeration of tissue mast cells experimental mouse models of disease isolation of mature mast cells mast cell activation state mast cell biology mast cell progenitors from mammalian tissues mast cell secretory mast cells in human health methods for the isolation phylogenetic profile tissue fibrosis

Editors and affiliations

  • Michael R. Hughes
    • 1
  • Kelly M. McNagny
    • 2
  1. 1.Department of Medical GeneticsThe Biomedical Research Centre, University of British ColumbiaVancouverCanada
  2. 2.Department of Medical GeneticsThe Biomedical Research Centre, University of British ColumbiaVancouverCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-1568-2
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-1567-5
  • Online ISBN 978-1-4939-1568-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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