Microglia in Health and Disease

  • Marie-Ève Tremblay
  • Amanda Sierra

Table of contents

  1. Front Matter
    Pages i-xiv
  2. The General Setting

    1. Front Matter
      Pages 1-1
    2. Amanda Sierra, Marie-Ève Tremblay
      Pages 3-6
    3. Payam Rezaie, Uwe-Karsten Hanisch
      Pages 7-46
    4. Jyoti J. Watters, Jennifer M. Pocock
      Pages 47-79
    5. Dimitrios Davalos, Martin Fuhrmann
      Pages 81-114
    6. Richa Hanamsagar, Sandra M. Cardona, Tammy Kielian, Astrid E. Cardona
      Pages 115-144
    7. Knut Biber, Michelle L. Block
      Pages 145-172
  3. What Is on Stage The New Roles

    1. Front Matter
      Pages 173-173
    2. José L. Marín-Teva, Julio Navascués, Ana Sierra, Michel Mallat
      Pages 175-192
    3. Marie-Ève Tremblay, Rosa C. Paolicelli, Beth Stevens, Hiroaki Wake, Alain Bessis
      Pages 223-248
    4. Amanda Sierra, Marie-Ève Tremblay
      Pages 249-271
    5. Jessica K. Alexander, Simon Beggs, Michael W. Salter
      Pages 273-297
    6. Xiaohui Wang, Thomas A. Cochran, Mark R. Hutchinson, Hang Yin, Linda R. Watkins
      Pages 299-317
    7. Rommy von Bernhardi, Betsi Flores, Hiroshi Nakanishi
      Pages 319-341
  4. Their Pathological Implications Conditions Impacting on the Quality of Life

    1. Front Matter
      Pages 343-343
    2. Akira Monji, Izumi Maezawa, Yoshito Mizoguchi, Takahiro A. Kato, Lee-Way Jin
      Pages 345-372
    3. Daniel F. Marker, Shao-Ming Lu, Harris A. Gelbard
      Pages 373-392
    4. Yoshifumi Sonobe, Akio Suzumura
      Pages 393-412
    5. Raffaela Cipriani, Maria Domercq, Carlos Matute
      Pages 413-435
    6. Diego Gomez-Nicola, V. Hugh Perry
      Pages 437-453
    7. Samuel David, Phillip G. Popovich
      Pages 455-472
  5. Back Matter
    Pages 473-486

About this book


These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents.

To set microglia on the stage, the book begins by explaining briefly what they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.


aging microglia microglia and disease microglia in health neural development

Editors and affiliations

  • Marie-Ève Tremblay
    • 1
  • Amanda Sierra
    • 2
  1. 1.Axe Neurosciences, Centre de recherche du, CHU de Québec, and Department of Molecular MedicineUniversité LavalQuébecCanada
  2. 2.Achucarro Basque Center for NeuroscienceUniversity of the Basque Country, EHU/UPV, Ikerbasque FoundationZamudio, BizkaiaSpain

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