Macrophages: Biology and Role in the Pathology of Diseases

  • Subhra K. Biswas
  • Alberto Mantovani

Table of contents

  1. Front Matter
    Pages i-ix
  2. Macrophage: Origin, Activation and Polarization

    1. Front Matter
      Pages 1-1
    2. Loems Ziegler-Heitbrock
      Pages 3-36
    3. Maria Rosaria Galdiero, Subhra K. Biswas, Alberto Mantovani
      Pages 37-57
    4. Siamon Gordon, Laura Helming, Fernando O. Martinez Estrada
      Pages 59-76
    5. David M. Mosser, C. Andrew Stewart
      Pages 77-87
  3. Macrophages and Their Diverse Functions

    1. Front Matter
      Pages 89-89
    2. Andrea J. Wolf, David M. Underhill
      Pages 91-109
    3. Ronald S. Flannagan
      Pages 111-129
    4. Ioanna Keklikoglou, Michele De Palma
      Pages 131-168
  4. Macrophages in Different Tissues

    1. Front Matter
      Pages 169-169
    2. Tracy Hussell, Thomas J. Bell, Toshifumi Fujimori
      Pages 171-182
    3. Guillaume Hoeffel, Paola Squarzoni, Sonia Garel, Florent Ginhoux
      Pages 183-215
    4. Andrea M. Woltman, Andre Boonstra, Makoto Naito, Pieter J. M. Leenen
      Pages 217-247
  5. Macrophages in Pathology

    1. Front Matter
      Pages 267-267
    2. Meredith J. Crane, Jorge E. Albina
      Pages 269-286
    3. Charles N. Serhan, Nan Chiang, Jesmond Dalli
      Pages 287-314
    4. Eduardo López-Collazo, Jean-Marc Cavaillon, Subhra K. Biswas
      Pages 315-338
    5. Mihai G. Netea, Alberto Mantovani
      Pages 339-348
    6. G. Chinetti-Gbaguidi, B. Staels
      Pages 375-385
    7. Jo A. Van Ginderachter
      Pages 405-423
    8. Antonio Sica, Laura Straus, Paola Allavena
      Pages 425-443
  6. Transcriptional and Epigenetic Mechanisms

    1. Front Matter
      Pages 445-445
    2. Toby Lawrence
      Pages 447-462
    3. Lalitha Nayak, Derin Tugal, Mukesh K. Jain
      Pages 487-495
    4. Sandra E. Nicholson, Peter J. Murray
      Pages 497-508
    5. Michito Hamada, Satoru Takahashi
      Pages 509-517
    6. Renato Ostuni, Gioacchino Natoli
      Pages 519-543
    7. Graziella Curtale, Massimo Locati
      Pages 545-555
  7. Systems Biology of Macrophages

    1. Front Matter
      Pages 557-557
    2. Ronny Milde, Matthieu Pesant, Massimo Locati, Fernando O. Martinez Estrada
      Pages 559-585
    3. Shakti Gupta, Ashok Reddy Dinasarapu, Merril J. Gersten, Mano Ram Maurya, Shankar Subramaniam
      Pages 587-615

About this book


Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue microenvironmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells.

Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease- virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts to provide state-of-the art knowledge of these cells in health and disease.


disease homeostasis immune system inflammation macrophages microenvironment

Editors and affiliations

  • Subhra K. Biswas
    • 1
  • Alberto Mantovani
    • 2
  1. 1.Singapore Immunology Network (SIgN) Biomedical Sciences Institutes, A*STARSingaporeSingapore
  2. 2.IRCCS Humanitas Clinical and Research Institute, Humanitas UniversityRozzanoItaly

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