Table of contents
A Global View of the Chaperone Network
Chaperones at the Ribosome
The Hsp70 and Hsp40 Chaperone Networks
The Hsp90 Chaperone Network
The p23 Chaperone Network
Chaperone Networks in Organelles
The Ubiquitin-Proteasome System Network
The Chaperone and Protease Networks in Model Bacteria and Parasites
About this book
Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion.
In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases.
This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective.
Editors and affiliations
- DOI https://doi.org/10.1007/978-1-4939-1130-1
- Copyright Information Springer Science+Business Media New York 2014
- Publisher Name Springer, New York, NY
- eBook Packages Biomedical and Life Sciences
- Print ISBN 978-1-4939-1129-5
- Online ISBN 978-1-4939-1130-1
- Buy this book on publisher's site