Cholesterol Transporters of the START Domain Protein Family in Health and Disease

START Proteins - Structure and Function

  • Barbara J. Clark
  • Douglas M. Stocco

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Barbara J. Clark, Douglas M. Stocco
    Pages 15-47
  3. Danny Létourneau, Pierre Lavigne, Andrée Lefebvre, Jean-Guy LeHoux
    Pages 49-72
  4. Walter L. Miller
    Pages 73-97
  5. Annette Graham, Faye Borthwick, Janice Taylor
    Pages 99-117
  6. Fabien Alpy, Catherine L. Tomasetto
    Pages 119-138
  7. Back Matter
    Pages 189-190

About this book


Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis. This is an exciting new direction in the field and the purpose of this book will be to highlight the current research directed at potential roles for the START family in diabetes, cancer, and atherogenesis.

This book also provides a personal and historical perspective of the discovery-to-publication journey that the authors had for their particular START domain family member. The goal will be to provide perspectives to graduate students, post-doctoral fellows, and endocrinology fellows on the research discovery process.


cholesterol homeostasis cholesterol transport endocrinology start transporters

Editors and affiliations

  • Barbara J. Clark
    • 1
  • Douglas M. Stocco
    • 2
  1. 1.Biochemistry and Molecular BiologyUniversity of Louisville School of MedicineLouisvilleUSA
  2. 2.Cell Biology and BiochemistryTexas Tech Univ. Health Sciences CenterLubbockUSA

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