Oral Mucosal Drug Delivery and Therapy

  • Michael J. Rathbone
  • Sevda Senel
  • Indiran Pather

Part of the Advances in Delivery Science and Technology book series (ADST)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Thomas P. Johnston
    Pages 1-15
  3. Michael John Rathbone, Indiran Pather, Sevda Şenel
    Pages 17-29
  4. Indiran Pather, Chandra Sekhar Kolli
    Pages 31-52
  5. Giuseppina Sandri, Silvia Rossi, Franca Ferrari, Maria Cristina Bonferoni, Carla M. Caramella
    Pages 53-88
  6. Chandra Sekhar Kolli, Indiran Pather
    Pages 125-148
  7. Michael John Rathbone, Sevda Şenel, Indiran Pather
    Pages 149-167
  8. Carla M. Caramella, Maria Cristina Bonferoni, Giuseppina Sandri, Eleonora Dellera, Silvia Rossi, Franca Ferrari et al.
    Pages 225-245
  9. Back Matter
    Pages 275-279

About this book


This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods.


In 11 authoritative chapters, the book affords an in-depth evaluation of the major issues associated with this route of administration, namely the retention of the drug/product at the site of administration and increasing drug permeability through the oral mucosa.  The book provides insights into the in vitro and in vivo methods available to assess drug permeability and retention, offers solutions on how to improve the permeation of the drugs through the oral mucosa, and explores approaches to prolong drug/product retention at the site of administration. It also indicates future directions in research and product development. Oral Mucosal Drug Delivery and Therapy is a key resource for those wishing to extend their knowledge of this field.


delivery systems membranes oral cavity permeation transmucosal

Editors and affiliations

  • Michael J. Rathbone
    • 1
  • Sevda Senel
    • 2
  • Indiran Pather
    • 3
  1. 1.Ulti Pharmaceuticals Ltd.HamiltonNew Zealand
  2. 2.Hacettepe University, Faculty of PharmacyAnkaraTurkey
  3. 3.California Northstate University, College of PharmacyElk GroveUSA

Bibliographic information

  • DOI
  • Copyright Information Controlled Release Society 2015
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4899-7557-7
  • Online ISBN 978-1-4899-7558-4
  • Series Print ISSN 2192-6204
  • Series Online ISSN 2192-6212
  • Buy this book on publisher's site
Industry Sectors
Chemical Manufacturing
Consumer Packaged Goods