Bone Drugs in Pediatrics

Efficacy and Challenges

  • Gordon L. Klein

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Gordon L. Klein
    Pages 1-3
  3. Michael D. Reed, Michelle L. Bestic
    Pages 5-22
  4. John G. Logan, J. H. Duncan Bassett, Moira S. Cheung
    Pages 37-65
  5. Andrew Biggin, Craig F. Munns
    Pages 67-80
  6. Gordon L. Klein
    Pages 101-115
  7. Daisuke Harada, Yoshiki Seino
    Pages 117-134
  8. Nigel Tapiwa Mabvuure, Alexis N. Thomas, Linda E. Sousse
    Pages 135-152
  9. Melissa S. Putman, Catherine M. Gordon
    Pages 153-181
  10. Srinivas M. Susarla, Christina M. Jacobsen, Shelly Abramowicz
    Pages 183-198
  11. Natalie E. Cusano, Aline G. Costa, Barbara C. Silva, John P. Bilezekian
    Pages 199-221
  12. Back Matter
    Pages 225-233

About this book


Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves – such as bisphosphonates, anti-resorptives and anabolic agents – within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.


Anti-resorptive Bisphosphonate Growth hormone Oxandralone Pediatric bone drugs Pediatric bone loss Pediatric pharmacology

Editors and affiliations

  • Gordon L. Klein
    • 1
  1. 1.Department of Orthopaedic SurgeryUniversity of Texas Medical BranchGalvestonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-1-4899-7435-8
  • Online ISBN 978-1-4899-7436-5
  • Buy this book on publisher's site
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