Tissue Renin-Angiotensin Systems

1. Front Matter

   Pages i-xi

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2. Frontiers in Reproductive Physiology

   1. The Mammalian Pineal Gland and Reproduction

      • James Olcese

      Pages 1-14

   2. Neuroendocrine Control of Reproduction

      • Richard W. Steger, Andrzej Bartke

      Pages 15-32

   3. Endocrine, Paracrine and Autocrine Regulation of Testicular Steroidogenesis

      • Ilpo Huhtaniemi, Jorma Toppari

      Pages 33-54

   4. Gonadotrophin Control of Testicular Germ Cell Development

      • Gerhard F. Weinbauer, Eberhard Nieschlag

      Pages 55-65

   5. Current Aspects of Autocrine and Paracrine Regulation of Spermatogenesis

      • Bernard Jégou, Charles Pineau

      Pages 67-86

   6. Role of the Epididymis in Mediating Changes in the Male Gamete during Maturation

      • T. G. Cooper

      Pages 87-101

   7. Ovarian Follicular Growth, Ovulation and Atresia

      • Kelle H. Moley, James R. Schreiber

      Pages 103-119

   8. Ovulation as a Tissue Remodelling Process

      • Alex Tsafriri

      Pages 121-140

3. Prorenin-Renin-Angiotensin System: Novel Aspects and Recent Advances

   1. Biochemistry and Cell Biology of Angiotensin-Converting Enzyme and Converting Enzyme Inhibitors

      • Kathleen H. Berecek, Lin Zhang

      Pages 141-168

   2. Angiotensin II Receptors

      • Robert C. Speth, Steven M. Thompson, Susan J. Johns

      Pages 169-192

   3. The Angiotensin Type 1 and Type 2 Receptor Families

      • Steven J. Fluharty, Lawrence P. Reagan, Daniel K. Yee

      Pages 193-215

   4. Angiotensin II in Cell Growth and Matrix Production

      • Willa A. Hsueh, Yung S. Do, Pamela W. Anderson, Ronald E. Law

      Pages 217-223

   5. Angiotensin as a Renal Growth Promoting Factor

      • Gunter Wolf

      Pages 225-236

   6. The Adrenal Renin/Angiotensin System

      • G. P. Vinson

      Pages 237-251

   7. The Tissue Renin-Angiotensin System in the Female Reproductive Tissues

      • A. H. Nielsen, A. Hagemann, K. Poulsen

      Pages 253-268

   8. Relevance of the Tissue Prorenin-Renin-Angiotensin System to Male Reproductive Physiology

      • Amal K. Mukhopadhyay, Joana Cobilanschi, Bärbel Brunswig-Spickenheier, Freimut A. Leidenberger

      Pages 269-277

4. Proceedings of the Symposium on Tissue Prorenin-Renin-Angiotensin Systems: Local Regulatory Actions in Reproductive and Endocrine Organs Hamburg, Germany, July 1–16, 1994

   1. Role of the Cardiac Renin-Angiotensin System in Human Heart Failure

      • Martin Paul, Philippe Stock, Matthias Langheinrich, Lutz Liefeldt, Gilbert Schönfelder, Michael Böhm

      Pages 279-283

   2. Transcriptional Silencer in Intron I of the Rat Renin Gene

      • T. Voigtländer, A. Ripperger, D. Ganten, M. Bader

      Pages 285-292

   3. In Field-Stimulated Guinea-Pig Atria an AT1-Receptor Mediated Increase of Noradrenaline Release by Angiotensin II is Seen only in the Presence of Prejunctional Autoinhibition

      • H. Brasch, L. Sieroslawski, N. Bergmann, P. Dominiak

      Pages 293-298

Recent progress in recombinant DNA technology and the availability of a number of nonpeptide subtype-specific receptor antagonists and of specific antibodies to components of prorenin-renin-angiotensin system (PRAS) have led to rapid advances in the under­ standing of the multifaceted role of angiotensin II, classically known as a peptide hormone of cardiovascular homeostasis. Accumulating evidence sug­ responsible for the regulation gests that, in addition to its role in salt and water metabolism, PRAS may control other physiological functions including neurosecretion, cellular proliferation, hypertrophy and/or differentiation, angiogenesis and gonadal function. At the same time, it is becoming evident that the specialized functions of endocrine glands are not only regulated by trophic hormones but also by locally produced paracrine/autocrine factors. The concept is emerging that tissue PRAS is one such locally active regulatory system. With more and more reproductive and endocrine organs being added to the list of tissues that contain a local tissue PRAS, questions are being raised by the reproductive biologists and endocrinologists as to the role of such systems in the tissues of their interest. On the other hand, the cardiovascular and renovascular physiologists are wondering about the relevance of PRAS in various peripheral tissues compared to those of the classical cardiovascular organs. It appeared, therefore, that the time was ripe for a meeting to consider a merger of interest in these two important but heretofore distinct areas of physiology.

• Angiotensin II
• Peptide
• enzymes
• genes
• pathophysiology
• physiology
• prolactin
• tissue
• diabetes

• Institute for Hormone and Fertility Research, University of Hamburg, Hamburg, Germany

  Amal K. Mukhopadhyay

• University of Florida, Gainesville, USA

  Mohan K. Raizada

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