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Mechanisms of Lymphocyte Activation and Immune Regulation VI

Cell Cycle and Programmed Cell Death in the Immune System

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 406)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-ix
  2. Cell Cycle and Signaling Pathways in Apoptosis

    1. Apoptosis/Programmed Cell Death

      • Sudhir Gupta
      Pages 1-9
    2. Apoptosis and Its Regulation

      • J. John Cohen
      Pages 11-20
    3. Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages

      • Robert A. Schlegel, Melissa Callahan, Stephen Krahling, Deepti Pradhan, Patrick Williamson
      Pages 21-28
    4. Cytotoxic Lymphocyte Killing Enters the Ice Age

      • Seamus J. Martin, Gustavo P. Amarante-Mendes, Douglas R. Green
      Pages 29-37
    5. Cross-Talk between Ceramide and PKC Activity in the Control of Apoptosis in WEHI-231

      • Steven J. Chmura, Edwardine Nodzenski, Mary A. Crane, Subbulakshmi Virudachalam, Dennis E. Hallahan, Ralph R. Weichselbaum et al.
      Pages 39-55
    6. Cell Cycle Control of T Cell Apoptosis Induced by Activation Through the T Cell Antigen Receptor

      • N. Jan Chalupny, Liqing Zhu, Xue-zhong Yu, Claudio Anasetti
      Pages 57-67
    7. Role of Antibody Signaling in Inducing Tumor Dormancy

      • Jonathan W. Uhr, Radu Marches, Emil Racila, Thomas F. Tucker, Robert Hsueh, Nancy E. Street et al.
      Pages 69-74
  3. Apoptosis-Regulating Genes

    1. Regulation of Lymphoid Apoptosis by Bcl-2 and Bcl-xL

      • Gabriel Nuñez, Ramon Merino, Philip L. Simonian, Didier A. M. Grillot
      Pages 75-82
    2. Structure—Function Analysis of Bcl-2 Family Proteins

      • John C. Reed, Hongbin Zha, Christine Aime-Sempe, Shinichi Takayama, Hong-Gang Wang
      Pages 99-112
    3. Role of Ice-Proteases in Apoptosis

      • Vishva M. Dixit
      Pages 113-117
    4. Fas-Mediated Apoptosis

      • Shigekazu Nagata
      Pages 119-124
    5. Fas Splicing Variants and their Effect on Apoptosis

      • Giovina Ruberti, Isabella Cascino, Giuliana Papoff, Adriana Eramo
      Pages 125-134
  4. Apoptosis in B Cells

    1. Signals for Survival and Apoptosis in Normal and Neoplastic B Lymphocytes

      • John Gordon, Christopher D. Gregory, Gillian Grafton, John D. Pound
      Pages 139-144
    2. Regulation of B Cell Apoptosis

      • Robert F. Ashman, David Peckham, Laura L. Stunz
      Pages 145-154
    3. Apoptotic Cell Death in the Chicken Bursa of Fabricius

      • Karen A. Jacobsen, Eustache Paramithiotis, Don L. Ewert, Michael J. H. Ratcliffe
      Pages 155-165
    4. Generation and Regulation of B Cell Autoreactivity Arising in the Periphery

      • Philip Kuo, Daniel Michael, Boaz Tadmor, Betty Diamond
      Pages 167-176
    5. Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes

      • Thomas L. Rothstein, Linda C. Foote, Thomas J. Schneider, Gavin M. Fischer, Bruce A. Jacobson, David H. Lynch et al.
      Pages 177-189

About this book

Since programmed cell death was first described in insects in 1964 and apoptosis was described in 1972, rapid progress has been made in understanding the basic mechanisms and genes regulating programmed cell death and apoptosis. In addition, defects in various genes regulating programmed cell death have been delineated in several experimental models of human diseases. This volume surveys various aspects of these rapidly developing areas of research in programmed cell death/apoptosis. This volume should be of interest to basic immunologists and molecular biologists. The volume begins with a historical perspective of cell death. The remainder of the volume is divided into four different parts. Part I deals with the signaling pathways in apoptosis, including cell cycle control of apoptosis, role of ceramide in apoptosis, role of antibody signaling, and biochemical regulation of apoptosis. The mechanisms for recognition of apoptotic lymphocytes by macrophages are also reviewed. Part II examines the role of various genes that regulate apoptosis, including the role ofFas, FasL, and other TNF family members in apoptosis and homeostatic regulation of immune response. Recently described splice variants and their influence on apoptosis are also reviewed, and the role of the members of the Bcl-2 family in apoptosis is discussed in detail. Part III reviews various aspects of apoptosis in B lymphocytes, including mechanisms that regulate apoptosis/survival of B lymphocytes and the regulation of Fas-mediated apoptosis in B lymphocytes.

Keywords

  • T cell
  • Thymus
  • apoptosis
  • diseases
  • insects
  • lymphocytes
  • macrophages
  • programmed cell death
  • proteins
  • virus

Reviews

`This book is a valuable addition to the literature.'
Quarterly Review of Biology, March 1998

Editors and Affiliations

  • University of California, Irvine, Irvine, USA

    Sudhir Gupta

  • University of Colorado Health Sciences Center, Denver, USA

    J. John Cohen

Bibliographic Information

Buying options

eBook USD 119.00
Price excludes VAT (USA)
  • ISBN: 978-1-4899-0274-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 159.99
Price excludes VAT (USA)
Hardcover Book USD 249.99
Price excludes VAT (USA)