Control of Metabolic Processes

1. Interconvertible Enzymes in Metabolic Control

   1. Regulation of Muscle Glycogenolysis

      • Ronald D. Edstrom, Marilyn H. Meinke, Mary E. Gurnack, David M. Steinhorn, Xiuru Yang, Rui Yang et al.

      Pages 209-217

2. Methods of Applying Control Analysis to Real Systems

   1. Front Matter

      Pages 219-219

      PDF

   2. Methodology for Simulation of Metabolic Pathways and Calculation of Control Coefficients

      • Pedro Mendes, João Moniz Barreto, Ana Vaz Gomes, Ana Ponces Freire

      Pages 221-224

   3. Regulatory Responses and Control Analysis: Assessment of the Relative Importance of Internal Effectors

      • Herbert M. Sauro

      Pages 225-230

   4. Determination of Control Coefficients by Shortening and Enzyme Titration of Metabolic Pathways

      • Enrique Meléndez-Hevia, Néstor V. Torres

      Pages 231-238

   5. Control-Pattern Analysis of Metabolic Systems

      • Jan-Hendrik S. Hofmeyr

      Pages 239-248

3. Channelling of Intermediates and the Time Domain

   1. Front Matter

      Pages 249-249

      PDF

   2. Control Analysis of Systems with Enzyme-Enzyme Interactions

      • Henrik Kacser, Herbert M. Sauro, Luis Acerenza

      Pages 251-257

   3. Coupled Reactions and Channelling: their Role in the Control of Metabolism

      • Tamás Keleti

      Pages 259-270

   4. Channelling and Channel Efficiency: Theory and Analytical Implications

      • Judit Ovádi

      Pages 271-279

   5. Temporal Analysis of the Transition between Steady States

      • John S. Easterby

      Pages 281-290

   6. Sensing of Chemical Signals by Enzymes

      • Jacques Ricard, Jean Buc, Nicolas Kellershohn, Jean-Michel Soulié

      Pages 291-296

   7. Temporal Aspects of the Control of Metabolic Processes

      • Luis Acerenza

      Pages 297-302

   8. Control of Metabolic Oscillations: Unpredictability, Critical Slowing Down, Optimal Stability and Hysteresis

      • Mario Markus, Benno Hess

      Pages 303-313

4. Experimental Applications

   1. Front Matter

      Pages 315-315

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   2. A New Method for Estimating Enzyme Activity and Control Coefficients in vivo

      • Barbara E. Wright, Kathy R. Albe

      Pages 317-328

   3. Metabolic Control Analysis: Principles and Application to the Erythrocyte

      • Reinhart Heinrich

      Pages 329-342

   4. Constraints in the Application of Control Analysis to the Study of Metabolism in Hepatocytes

      • Michael N. Berry, Roland B. Gregory, Anthony R. Grivell, Debra C. Henly, John W. Phillips, Patricia G. Wallace et al.

      Pages 343-350

   5. Application of Metabolic Control Analysis to Photosynthesis: the Problem of Getting Data for an Impressive Algorithm

      • Christoph Giersch, Dirk Lämmel, Klaus Steffen

      Pages 351-361

   6. Application of Control Analysis to Photosynthetic Sucrose Synthesis

      • Mark Stitt

      Pages 363-376

THIS BOOK collects together papers given at a NATO Advanced Research Workshop held at Il Ciocco (Lucca), Italy, from the 9th to the 15th April, 1989. It sets out to present the current state of understanding of the principles governing the way fluxes and concentrations are maintained and controlled in metabolic systems. Although this is a topic that has held the interest of biochemists for many years, it is only quite recently that the methods of analysing the kinetics of multi-enzyme pathways developed over the past two decades have come to be widely discussed or applied experimentally. Many biochemists remain sceptical that the new methods offer a real advance (except in complexity) over the landmark discoveries of the 1950s and 1960s relating to inhibition of enzymes at branch-points by the end products of metabolic pathways, and the interpretation of allosteric effects and cooperativity. Even those who have become convinced that the classical ideas provide only the starting point for understanding metabolic control have been by no means unanimous in their assess­ ment of the direction in which one should advance. In this book we have tried to include all of the current points of view, including the view that the classical theories tell us all that we need to know. We have not seen it as our role as editors to paper over the cracks that exist and to pretend that we can speak to the world with one voice.

• Amino acid
• Glutamin
• Glycogen
• Nucleotide
• Purine
• Termination
• biosynthesis
• enzymes
• gene expression
• genes
• metabolic control
• metabolism
• diabetes

• Center for Biochemistry and Molecular Biology—CNRS, Marseille, France

  Athel Cornish-Bowden, María Luz Cárdenas

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