Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular

1. ACE Inhibitors and Calcium Antagonists

   1. Front Matter

      Pages 133-133

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   2. Analysis of Angiotensin-Converting Enzyme Inhibitors in Biological Fluids

      • A. Rakhit

      Pages 135-142

   3. The Analysis of ACE Inhibitors by Immunoassay

      • J. D. Robinson, S. Lewis

      Pages 143-148

   4. The Use of Stable-Isotope Methodology in Pharmacokinetic Studies Involving Flunarizine

      • Robert Woestenborghs, Philip Timmerman, Achiel Van Peer, Jos Heykants

      Pages 149-155

2. Notes and Comments Relating to ACE Inhibitors and Calcium Antagonists

   1. Front Matter

      Pages 157-157

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   2. Assay Problems with Nifedipine

      • Peter S. B. Minty, Felicity A. Tucker

      Pages 159-161

   3. Detection of the Metabolites of Some Dihydropyridine-Type Calcium Antagonists in Urine and Plasma

      • K-D. Rämsch, D. Scherling

      Pages 163-166

3. Various Cardiovascular Drugs

   1. Front Matter

      Pages 167-167

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   2. The Study of Chiral Cardiovascular Drugs: Analytical Approaches and Some Pharmacological Consequences

      • Richard L. Lalonde, Michael B. Bottorff, Irving W. Wainer

      Pages 169-177

   3. Development of a Chiral Capillary GC Method for the Quantitation of the Enantiomers of Cromakalim in Biological Fluids

      • B. E. Davies

      Pages 179-183

   4. The Determination of Plasma Amiodarone and Desethylamiodarone by HPLC

      • B. J. Starkey, A. J. E. Green, G. P. Mould

      Pages 185-191

   5. The Assay of Hydralazine: A Review

      • P. H. Degen

      Pages 193-200

   6. Approaches to the Analysis of Two Cardiovascular Drugs in Plasma

      • R. D. McDowall, J. C. Pearce, G. S. Murkitt, J. A. Jelly, W. J. Leavens, K. A. Fernandes et al.

      Pages 201-206

4. Notes and Comments Relating to Various Cardiovascular Drugs

   1. Front Matter

      Pages 207-207

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   2. Quantitative Analysis of Flesinoxan in Plasma and Urine at the pg/ml Level Using GC-ECD

      • M. P. van Berkel, H. de Bree, K. Sierat

      Pages 209-212

   3. Assay of Nitroglycerin and Metabolites by Capillary GC

      • Stephen H. Curry, Hae-Ryun Kwon

      Pages 213-214

   4. HPLC-Fluorescence Method for the Determination of the New β1-Adrenoreceptor Blocking Agent Nebivolol in Human Plasma

      • Robert Woestenborghs, Luc Embrechts, Jos Heykants

      Pages 215-222

5. Various Drugs and Separatory Approaches

   1. Front Matter

      Pages 223-223

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   2. The Routine Use, and Column-Stability Implications, of Several Column-Switching HPLC Methods for Determining Drugs in Plasma and Urine

      • J. B. Lecaillon, C. Souppart, J. P. Dubois, A. Delacroix

      Pages 225-233

   3. Micellar Liquid Chromatography

      • John G. Dorsey

      Pages 235-244

vi as did non-appreciation that % values for bought-in solutions (notably ammonia) may be on a weight basis, not made evident by the manufacturer. Notwithstanding the shortcomings or lateness of some texts, authors are thanked for compiling them amidst other pressures. Elsevier and the American Chemical Society are also thanked, for Figures now reproduced with source acknowledgement. This Editor has generally respected authors' phrasing, whilst shuddering when the term 'incubate' is encountered in a 0° context. He remains a 'diehard' in certain respects, notably in favouring 'M' rather than 'mol/I', and a wt./ml basis for drug concentrations in test samples; he regards 'mmol/l' as a fatuous fashion. Concerning infelicitous abbreviations, a distinction is made between electron­ capture (detector context; 'ECD') and electrochemical ('EC', never 'ECD'); the hallowed GC term 'FID' means free induction decay to NMR practi tione:ts, who may pardon the term 'Fid' as introduced editorially. The convention for ,0C' throughout the book is '0'. Undefined but well-known abbreviations include GC, HPLC and TLC. MS (mass spectrometry), NPD (nitrogen-phosphorus detector), tr (retention time) and RIA (radioimmunoassay) are usually defined in the article concerned, as are the HPLC modes NP (normal-/straight­ phase) and RP (reversed-phase; C-lS and ODS are synonymous), and i.s.

• Mass Spectrometry
• NMR
• drug
• nitrogen
• nuclear magnetic resonance (NMR)
• phase
• phosphorus
• research
• society
• spectrometry

• Guildford Academic Associates, Guildford, UK

  Eric Reid

• Hoechst UK, Milton Keynes, UK

  J. D. Robinson

• ICI Pharmaceuticals Division, Macclesfield, UK

  Ian D. Wilson

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