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  • © 1994

Angiogenesis

Molecular Biology, Clinical Aspects

Part of the book series: NATO Science Series A: (NSSA, volume 263)

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  • ISBN: 978-1-4757-9188-4
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Table of contents (37 chapters)

  1. Front Matter

    Pages i-x
  2. Embryonic Development and Angiogenesis

    1. Embryology of the Endothelial Network: Is There an Hemangioblastic Anlage ?

      • Françoise Dieterlen-Lièvre, Dominique Luton, Luc Pardanaud
      Pages 1-8
    2. Endothelial Cell Heterogeneity and Organ — Specificity

      • Peter I. Lelkes, Vangelis G. Manolopoulos, Dawn Chick, Brian R. Unsworth
      Pages 15-28
  3. Molecular Biology of Angiogenesis

    1. Human Basic Fibroblast Growth Factor: Structure-Function Relationship of an Angiogenic Molecule

      • Marco Presta, Marco Rusnati, Anna Gualandris, Patrizia Dell’Era, Chiara Urbinati, Daniela Coltrini et al.
      Pages 39-50
    2. Angiogenesis Models Identify Factors Which Regulate Endothelial Cell Differentiation

      • D. S. Grant, D. Morales, M. C. Cid, H. K. Kleinman
      Pages 51-60
    3. P1GF: Placenta Derived Growth Factor

      • Domenico Maglione, Maria Graziella Persico
      Pages 73-80
    4. The Proliferative Effect of Substance P on Capillary Endothelial Cells is Mediated by Nitric Oxide

      • M. Ziche, L. Morbidelli, L. Mantelli, E. Masini, F. Ledda, H. J. Granger et al.
      Pages 91-96
    5. Interactions between Oxidized Lipoprotein (a) [Lp(a)], Monocytes and Endothelial Cells

      • Mahmoud Ragab, Periasamy Selvaraj, Demetrios S. Sgoutas
      Pages 103-109
    6. Altered Proliferation of Retinal Microvascular Cells in Response to Non-Enzymatic Glycosylated Matrix Proteins

      • Theodosia A. Kalfa, Mary E. Gerritsen, Effie C. Tsilibary
      Pages 111-118
    7. A Novel Laminin Domain Involved in Adhesion of Endothelial Cells

      • Aristidis Charonis, Nitsa Koliakos, George Koliakos, Gregg Fields, Lorrel Regger, Carrie Lynch et al.
      Pages 119-123
  4. Regulation of Angiogenesis

    1. Regulation of Angiogenesis: The Role of Protein Kinase, Nitric Oxide, Thrombin and Basement Membrane Synthesis

      • M. E. Maragoudakis, N. E. Tsopanoglou, G. C. Haralabopoulos, E. Sakkoula, E. Pipili-Synetos, E. Missirlis
      Pages 125-134
    2. Basement Membrane Laminin-Derived Peptide Sikvav Promotes Angiogenesis and Tumor Growth

      • Hynda K. Kleinman, Derrick S. Grant, Maura C. Kibbey
      Pages 135-141
    3. Angiogenesis in Vitro: Cytokine Interactions and Balanced Extracellular Proteolysis

      • Michael S. Pepper, Jean-Dominique Vassalli, Lelio Orci, Roberto Montesano
      Pages 149-170

About this book

Angiogenesis is a multistep process, which involves activation, proliferation and directed migration of endothelial cells to form new capillaries from existing vessels. Under physiological conditions, in the adult organisms angiogenesis is extremely slow, yet it can be activated for a limited time only in situations such as ovulation or wound healing. In a number of disease states, however, there is a derangement of angiogenesis, which can contribute to the pathology of these conditions. Hence, understanding the molecular biology of endothelial cell activation and differentiation and the mechanisms involved in the regulation of angiogenesis, could explain the derangement in disease states and also provide the basis for developing promoters or suppressors of angiogenesis for clinical applications. This book contains the proceedings of the NATO Advanced Study Institute on "Angiogenesis: Molecular Biology, Oinical Aspects" held in Rhodes, Greece, from June 16-27, 1993. This meeting was a comprehensive review of the various aspects of angiogenesis such as embryonic development, endothelial cell heterogeneity and tissue specificity, molecular biology of endothelial cell, mechanisms for the regulation of angiogenesis, disease states in which angiogenesis is involved and potential application of promoters or suppressors of angiogenesis. The presentations and discussions of the meeting provided an opportunity for investigators from many different areas of basic science and medicine to exchange information, evaluate the present status and provide future research directions in the field of angiogenesis.

Keywords

  • Embryo
  • Promoter
  • biology
  • development
  • growth
  • migration
  • molecular biology
  • proliferation
  • protein
  • research
  • tissue

Editors and Affiliations

  • University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

  • University of Torino Medical School, Torino, Italy

    Pietro M. Gullino

  • University of Wisconsin Medical School, Milwaukee, USA

    Peter I. Lelkes

Bibliographic Information

Buying options

eBook USD 139.00
Price excludes VAT (USA)
  • ISBN: 978-1-4757-9188-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 179.99
Price excludes VAT (USA)
Hardcover Book USD 279.99
Price excludes VAT (USA)