Biocatalysts for Industry

1. Front Matter

   Pages i-xvi

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2. The General Uses of Biocatalysts

   1. Front Matter

      Pages 1-1

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   2. An Introduction to Industrial Biocatalysis

      • Jonathan S. Dordick

      Pages 3-19

   3. Historical Perspective on the Industrial Uses of Biocatalysts

      • S. L. Neidleman

      Pages 21-33

3. Biocatalysts without Chemical Competition

   1. Front Matter

      Pages 35-35

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   2. Enzymatic Depolymerization of Starch

      • Zivko L. Nikolov, Peter J. Reilly

      Pages 37-62

   3. Biocatalysis in the Production of Carbohydrates for Food Uses

      • Andrew J. Hacking

      Pages 63-82

   4. Biocatalysts for the Synthesis and Modification of Biopolymers

      • Robert J. Linhardt, Ali Al-Hakim

      Pages 83-112

4. Emerging Biocatalysts for Conventional Chemical Processing

   1. Front Matter

      Pages 113-113

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   2. Lignin-Degrading Enzymes from the Filamentous Fungus Phanerochaete chrysosporium

      • Elizabeth A. Pease, Ming Tien

      Pages 115-135

   3. Microbial Biocatalysis for the Alteration of Fossil Fuels

      • Michael E. McIlwain, Patrick R. Dugan

      Pages 137-160

   4. Enzymes in Organic Solvents

      • Aleksey Zaks

      Pages 161-180

   5. Catalysis by Alcohol Dehydrogenases in Organic Solvents

      • Jeffrey S. Deetz, J. David Rozzell

      Pages 181-191

   6. Lipase Catalysis and Its Applications

      • Vijay T. John, George Abraham

      Pages 193-217

   7. Biocatalysis in Supercritical Fluids

      • Theodore W. Randolph, Harvey W. Blanch, Douglas S. Clark

      Pages 219-237

5. Future Directions of Biocatalysts

   1. Front Matter

      Pages 239-239

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   2. Protein Stabilization

      • Susan J. Tomazic

      Pages 241-255

   3. Protein Engineering of Subtilisin

      • Thomas P. Graycar

      Pages 257-283

   4. Catalytic Antibodies

      • David E. Hansen

      Pages 285-309

   5. Enzymatic Catalysis in Bioseparations

      • David G. Rethwisch, Jonathan S. Dordick

      Pages 311-323

The application of enzymes or whole cells (fermentatively active or resting; microbial, plant, or animal) to carry out selective transformations of commercial importance is the central theme of industrial biocatalysis. Traditionally, biocatalysis has been in the domain of the life scientist or biochemical engineer. However, recent advances in this field have enabled biocatalytic processes to compete head on with, and in some cases out­ perform, conventional chemical processing. Chemo-biocatalytic systems are being developed thereby combining the most attractive features of bio­ catalysts, namely high specificity, with those of chemical catalysts, such as high reactivities and wide substrate specificities. Hence, synthetic chemists and chemical engineers are now beginning to use biocatalysts as highly selective reagents in chemical synthesis and processing. This book is about biocatalysts and their past, present, and potential applications in the food, pharmaceutical, and chemical industries. The con­ cept of the book did not emanate from a meeting. Rather, it is a compila­ tion of selected examples where biocatalysis either has already made a significant impact in the aforementioned industries, or has the potential to make a substantial contribution. I have been fortunate to have assembled contributions from world-class researchers in the field of biocatalysis. Their timely contributions are sincerely appreciated.

• antibody
• plant
• polymer
• protein
• supercritical fluid

• Department of Chemical and Biochemical Engineering, The University of Iowa, Iowa City, USA

  Jonathan S. Dordick

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