Overview
- Authors:
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Bohuslav Ošt’ádal
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Department of Developmental Cardiology Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech
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František Kolář
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Department of Developmental Cardiology Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech
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Table of contents (6 chapters)
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- Bohuslav Ošt’ádal, František Kolář
Pages 1-44
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- Bohuslav Ošt’ádal, František Kolář
Pages 45-63
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- Bohuslav Ošt’ádal, František Kolář
Pages 65-79
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- Bohuslav Ošt’ádal, František Kolář
Pages 81-87
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- Bohuslav Ošt’ádal, František Kolář
Pages 89-133
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- Bohuslav Ošt’ádal, František Kolář
Pages 135-148
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Back Matter
Pages 149-173
About this book
Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.
