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Contemporary Topics in Molecular Immunology

  • Book
  • © 1978

Overview

Editors:
  1. Ralph A. Reisfeld

    1. Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. F. P. Inman

    1. Department of Biochemistry, East Tennessee State University, Johnson City, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary topics in immunobiology (CTI)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Structure and Function of Serum and Membrane Immunoglobulin D (IgD)

    • Gerrie A. Leslie, Louis N. Martin
    Pages 1-49

  3. Analysis of Biclonal Immunoglobulins and Their Contributions to Understanding the Developmental Aspects of the Antibody Response

    • Daryl S. Fair, Robert G. Krueger
    Pages 51-93

  4. Conformational Flexibility in Immunoglobulins

    • Allen B. Edmundson, Kathryn R. Ely, Enrique E. Abola
    Pages 95-118

  5. The Effect of Antigen on Antibodies: Recent Studies

    • Henry Metzger
    Pages 119-152

  6. Molecular Interactions of Cells with Antibody and Complement: Influence of Metabolic and Physical Properties of the Target on the Outcome of Humoral Immune Attack

    • Sarkis H. Ohanian, Seymour I. Schlager, Tibor Borsos
    Pages 153-180

  7. Chemical Aspects of the Serum Anaphylatoxins

    • Tony E. Hugli
    Pages 181-214

  8. Hapten — Sandwich Labeling of Cell-Surface Antigens

    • Leon Wofsy, Claudia Henry, Salvatore Cammisuli
    Pages 215-237

  9. Human DR (Ia-Like) Antigens: Biological and Molecular Profile

    • Soldano Ferrone, James P. Allison, Michele A. Pellegrino
    Pages 239-281

  10. The Molecular Structure and Interrelationships of Murine T Lymphoid Cell-Surface Antigens

    • Fiona Hunter, John E. Mole, J. Claude Bennett
    Pages 283-317

  11. Functional and Structural Considerations in the Recognition of Virus-Infected Cells by Cytotoxic T Lymphocytes

    • T. J. Braciale, G. L. Ada, K. L. Yap
    Pages 319-364

  12. Molecular Events in Lymphocyte Activation: Role of Nonhistone Chromosomal Proteins in Regulating Gene Expression

    • Janet M. Decker, John J. Marchalonis
    Pages 365-413

  13. Back Matter

    Pages 415-425
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Keywords

About this book

New information is developing so rapidly in the entire field of immunology that one is unable to remain abreast of all advancing fronts. In many cases, consider­ able information has accumulated as the result of the efforts of many investigators, but the conclusions from the various laboratories have not been summarized recently in a comprehensible manner. One such situation has to do with work on IgD. An up-to-date report on this immunoglobulin was included in Volume 10f this series, but since that time there has been considerable progress in the deter­ mination of its structure and function. In the present volume Leslie and Martin have reviewed the accomplishments of recent years and the problems remaining to be solved. New information regarding the concentration of IgD in body fluids in normal and disease states is presented. Studies of the ontogeny of surface IgD in animals are described, and the fmdings imply that it may be important in the primary immune response. The role of IgD on lymphocyte surfaces is thoroughly discussed especially in terms of stimulating or suppressive combinations of signals delivered to the lymphocyte by agents which bind or alter the surface rt:ceptors. The authors conclude by proposing a model for plasma-cell differentiation which accounts fo~ the existence of triple Ig-bearing cells, many IgM-IgD-bearing cells, and the low percentage of cells bearing a single isotype. Sometimes the serum of an individual contains abnormally large amounts of two distinct, homogeneous populations of immunoglobulins.

Editors and Affiliations

  • Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

    Ralph A. Reisfeld

  • Department of Biochemistry, East Tennessee State University, Johnson City, USA

    F. P. Inman

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