The Rhabdoviruses

1. Front Matter

   Pages i-xviii

   PDF

2. The Family Rhabdoviridae

   • Fred Brown

   Pages 1-8

3. Rhabdovirus Biology and Infection

   • Robert R. Wagner

   Pages 9-74

4. Rhabdovirus Membrane and Maturation

   • Ranajit Pal, Robert R. Wagner

   Pages 75-128

5. Rhabdovirus Genomes and Their Products

   • John Rose, Manfred Schubert

   Pages 129-166

6. Rhabdovirus Genetics

   • Craig R. Pringle

   Pages 167-243

7. Transcription of Vesicular Stomatitis Virus

   • Suzanne Urjil Emerson

   Pages 245-269

8. The Role of Proteins in Vesicular Stomatitis Virus RNA Replication

   • Gail W. Wertz, Nancy L. Davis, John Patton

   Pages 271-296

9. Defective Interfering Rhabdoviruses

   • John J. Holland

   Pages 297-360

10. Rabies Viruses—Pathogenesis and Immunity

    • William H. Wunner

    Pages 361-426

11. Biology, Structure, and Replication of Plant Rhabdoviruses

    • A. O. Jackson, R. I. B. Francki, Douwe Zuidema

    Pages 427-508

12. The Ecology of Rhabdoviruses That Infect Vertebrates

    • Robert E. Shope, Robert B. Tesh

    Pages 509-534

13. Back Matter

    Pages 535-544

    PDF

The viruses of the family Rhabdoviridae have an exceedingly broad host range and are widely distributed throughout the animal and plant king­ doms. Animal rhabdoviruses infect and often cause disease in insects, fish, and mammals, including man. The prototype rhabdovirus, vesicular stomatitis virus !VSV), has been extensively studied and provides perhaps the best model system for studying negative-strand viruses. The popularity of VSV as a model system is to a considerable extent due to its relative simplicity and to its rapid growth, generally to high titer, in many cell types ranging from yeast to human. The nucleocapsids of these viruses also carry transcriptional and replicative functions that are expressed in cell-free systems. The first RNA-dependent RNA poly­ merase was described in VSV and its G protein provided an early model system for studying the synthesis, processing, and membrane insertion of mammalian glycoproteins. VSV is also highly cytopathogenic and has been studied quite extensively for its capacity to kill cells and to shut off cellular macromolecular synthesis. Even earlier, VSV was discovered to be highly susceptible to the action of interferons and has served ever since as a means for quantitating the activity of interferons. To my way of thinking, the spark that ignited the explosion of re­ search in this field was struck at the First International Colloquium on Rhabdoviruses, attended by 30 or so participants in Roscoff, France, in June 1972.

• Mammalia
• Pathogene
• RNA
• ecology
• infection
• protein
• transcription
• virus
• infectious diseases

• Department of Microbiology and Cancer Center, University of Virginia School of Medicine, Charlottesville, USA

  Robert R. Wagner

Policies and ethics