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Emerging Strategies in Neuroprotection

  • Book
  • © 1992

Overview

Editors:
  1. Paul J. Marangos

    1. NeuroTherapeutics Corp. and Center for Neurologic Study, San Diego, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Harbans Lal

    1. Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Neuroprotection (AN, volume 22)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xix
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  2. Preclinical Ischemia Model Systems

    1. Front Matter

      Pages 1-1
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    2. Primary Cultures for Testing Neuroprotective Drugs

      • Heike Oberpichler-Schwenk, Josef Krieglstein
      Pages 3-23

    3. Modeling Neurodegeneration and Neuroprotection in Hippocampal Slices

      • Avital Schurr, Benjamin M. Rigor
      Pages 24-43

    4. Stroke Models for Preclinical Trials of Neuroprotective Agents

      • Chung Y. Hsu, Yong Y. He, Teng N. Lin, Grace Wu, Paul J. Marangos
      Pages 44-56

    5. Animal Models of Ischemia

      • Justin A. Zivin
      Pages 57-75

    6. Head Trauma Model Systems

      • Ronald L. Hayes, C. Edward Dixon, Susan R. Carrin
      Pages 76-89

  3. Neuroprotective Approaches in Stroke and Head Trauma

    1. Front Matter

      Pages 91-91
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    2. Excitotoxicity, Cerebral Ischemia, and Neuroprotection by Competitive NMDA Receptor Antagonists

      • Dirk Sauer, Lourdes Massieu, Peter R. Allegrini, Hugo Amacker, Markus Schmutz, Graham E. Fagg
      Pages 93-105

    3. Excitatory Amino Acids and Neuroprotection

      • Brian Meldrum
      Pages 106-128

    4. Calcium Channel Blockers and Neuroprotection

      • Giora Feuerstein, Jackie Hunter, Frank C. Barone
      Pages 129-150

    5. Self-Defense of the Brain: Adenosinergic Strategies in Neurodegeneration

      • K. J. Dag, E. von Lubitz, Paul J. Marangos
      Pages 151-186

    6. Gangliosides: New Generation of Neuroprotective Agents

      • Sahebarao P. Mahadik
      Pages 187-223

    7. Lazaroids: Novel Cerebroprotective Antioxidants

      • Edward D. Hall
      Pages 224-237

    8. Membrane-Derived Lipid Second Messengers as Targets for Neuroprotection: Platelet-Activating Factor

      • Nicolas G. Bazan, Jacques M. Cluzel
      Pages 238-251

    9. Protection Against Oxidative Damage to CNS by α-Phenyl-tert-butyl Nitrone and Other Spin-Trapping Agents: A Novel Series of Nonlipid Free Radical Scavengers

      • Robert A. Floyd, John M. Carney
      Pages 252-272

    10. Insulin, Hypoglycemia, and Ischemic Neuroprotection

      • Roland N. Auer
      Pages 273-288

    11. Temperature Modulation of Neuronal Injury

      • Mordecai Y.-T. Globus, Raul Busto, W. Dalton Dietrich, Linda Sternau, Eiharu Morikawa, Myron D. Ginsberg
      Pages 289-306

  4. Clinical Endpoints for Neuroprotective Drugs

    1. Front Matter

      Pages 307-307
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    2. Clinical Trial Issues in Stroke Therapy

      • Richard C. Meibach
      Pages 309-325
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Keywords

About this book

SOLOMON H. SNYDER Receptor Research Reaches Neurology: Relevance to Neurodegenerative Diseases and Stroke President George Bush has heralded the 1990s as the decade of the brain, based largely on the rapid escalation of advances in the molecular neuro­ sciences and the likelihood that these will bear therapeutic fruit before the turn of the century. There is little doubt that the 1970s and 1980s have witnessed more remarkable advances in the molecular neurosciences than all of the preceding hundred years. Identification of receptor sites for drugs and neurotransmitters along with simple, sensitive, and specific means of monitoring them has made it possible to elucidate the mechanism of action for many known drugs and to identify new chemical entities as potential therapeutic agents. At the same time, the numbers of distinct neurotrans­ mitters have multiplied. Prior to 1970 only the biogenic amines were well accepted as transmitters. The early 1970s witnessed the gradual acceptance ofamino acids as major excitatory and inhibitory neurotransmitters. Identification of opiate receptors and the subsequent identification of the enkephalins as their endogenous ligands led to an appreciation of peptides as putative transmitters and the accumulation of as many as a hundred neuropeptides by the decade's end. In the 1980s the revolutions of molecular biology have been applied aggressively to the neurosciences with molecular cloning for neuropeptide precursors, many important neurochemical en­ zymes, and receptors for numerous transmitters.

Editors and Affiliations

  • NeuroTherapeutics Corp. and Center for Neurologic Study, San Diego, USA

    Paul J. Marangos

  • Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth, USA

    Harbans Lal

Bibliographic Information

  • Book Title: Emerging Strategies in Neuroprotection

  • Editors: Paul J. Marangos, Harbans Lal

  • Series Title: Advances in Neuroprotection

  • DOI: https://doi.org/10.1007/978-1-4684-6796-3

  • Publisher: Birkhäuser Boston, MA

  • eBook Packages: Springer Book Archive

  • Copyright Information: Birkh�user Boston 1992

  • Softcover ISBN: 978-1-4684-6798-7Published: 29 April 2012

  • eBook ISBN: 978-1-4684-6796-3Published: 21 November 2013

  • Edition Number: 1

  • Number of Pages: XIX, 359

  • Number of Illustrations: 8 b/w illustrations

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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