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Beneficial Effects of Endotoxins

  • Book
  • © 1983

Overview

Editors:
  1. Alois Nowotny

    1. Center for Oral Health Research, School of Dental Medicine, University of Pennsylvania, Philadelphia, USA

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Table of contents (28 chapters)

  1. Endotoxin-Induced Release of Colony-Stimulating Factor

    • Dov H. Pluznik
    Pages 397-413

  2. Colony-Stimulating Activity Induction in Patients with Acute Leukemia

    • Wolfgang Hinterberger, Wolfgang Graninger, Walter R. Paukovits
    Pages 415-432

  3. Effect of Endotoxin on Graft-versus-Host Reactions

    • P. Liacopoulos
    Pages 433-450

  4. The Effect of Endotoxins on Skin and Kidney Transplantation Reactions

    • Ewa SkopiÅ„ska-Różewska
    Pages 451-473

  5. Adoptive Immunotherapy of Leukemia by Endotoxin-Induced Modulation of the Graft-versus-Host Reaction

    • Robert L. Truitt
    Pages 475-496

  6. Enhancement of Nonspecific Resistance to Tumor by Endotoxin

    • R. Christopher Butler
    Pages 497-512

  7. Induced Enhanced Resistance to Transplantable Tumors in Mice

    • Paul H. Saluk
    Pages 513-527

  8. Enhancement of Antitumor Resistance by Mycobacterial Products and Endotoxin

    • Edgar Ribi, John L. Cantrell, Kuni Takayama, Ken-ichi Amano
    Pages 529-554

  9. Role of LPS in Recognition and Induced Disease Resistance in Plant Hosts of Pseudomonas solanacearum

    • T. L. Graham
    Pages 555-568

  10. Back Matter

    Pages 569-581
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Keywords

About this book

The study of endotoxins has undergone cycles of enthusiastic research followed by neglect and revival again due to newly described biological effects attributed to endotoxins. It is almost a generally applicable rule that both extremes in such fluctuations in the popularity of certain re­ search fields are unjustified. It is obvious that exaggerated expectations will lead to disappointments, and complete neglect of a once-exciting field is to be followed by renewed attention, if the scientific basis of earlier interest was solid and remained so throughout. The healing ef­ fect of fever was praised as nature's blessed cure, until it was discov­ ered that it is caused by bacteria. When it became evident that by careful application one can arrive at therapeutic doses without intro­ ducing shock and hypotension, the era of fever therapy began. During this time, indiscriminate use of pyrogens was so widespread that the high expectations had to be followed by disillusionment. Since then, in­ terest in endotoxins experienced a few more oscillations, with varying wavelengths and amplitudes, the latest being triggered by the mitotic effect of endotoxin. This led to justified excitement among researchers who study the activation of the cells of the lymphatic system and the consequences thereof, including the release of important mediator mol­ ecules. Fever therapy is passe, but the healing that often followed the ap­ plication of endotoxins remains a well-documented fact.

Editors and Affiliations

  • Center for Oral Health Research, School of Dental Medicine, University of Pennsylvania, Philadelphia, USA

    Alois Nowotny

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