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  • © 1991

Purine and Pyrimidine Metabolism in Man VII

Part B: Structural Biochemistry, Pathogenesis, and Metabolism

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 309B)

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Table of contents (87 chapters)

  1. Structural Biochemistry, Pathogenesis and Metabolism

    1. Structural Biochemistry

      1. A Strategy for the Creation of Mutations in Human HPRT-cDNA and the Expression of Recombinant Proteins in E.Coli
        • R. B. Gordon, D. T. Keough, B. T. Emmerson, M. L. Free, C. L. Gee, J. de Jersey
        Pages 95-99
      2. Molecular Analysis of Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency in Japanese Patients
        • Shin Fujimori, Tetsuo Tagaya, Noriko Yamaoka, Naoyuki Kamatani, Ieo Akaoka
        Pages 101-104
      3. Expression of Normal and Variant Human Hypoxanthine-Guanine Phosphoribosyltransferase in E. Coli
        • Beverly L. Davidson, Blake J. Roessler, Thomas D. Palella
        Pages 105-108
      4. HPRT Gene Mutations in a Female Lesch-Nyhan Patient
        • Nobuaki Ogasawara, Yasukazu Yamada, Haruko Goto
        Pages 109-112
      5. Molecular Analysis of Human hprt Gene Deletions and Duplications
        • Raymond J. Monnat Jr., Alden F. M. Hackmann, Teresa A. Chiaverotti, Grace A. Maresh
        Pages 113-116
      6. Rat Hypoxanthine Phosphoribosyltransferase cDNA Cloning and Sequence Analysis
        • Teresa A. Chiaverotti, Narayana Battula, Raymond J. Monnat Jr.
        Pages 117-120
      7. Identification of Two Independent Japanese Mutant HPRT Genes Using the PCR Technique
        • Yasukazu Yamada, Haruko Goto, Nobuaki Ogasawara
        Pages 121-124
      8. Identification of Distinct PRS1 Mutations in Two Patients with X-Linked Phosphoribosylpyrophosphate Synthetase Superactivity
        • Blake J. Roessler, Nimrod Golovoy, Thomas D. Palella, Steven Heidler, Michael A . Becker
        Pages 125-128
      9. Human Phosphoribosylpyrophosphate Synthetase (PRS) 2: An Independent Active, X Chromosone-Linked PRS Isoform
        • M. A. Becker, S. A. Heidler, J. M. Nosal, R. L. Switzer, M. M. LeBeau, L. J. Shapiro et al.
        Pages 129-132
      10. A Genetic Defect in Muscle Phosphofructokinase Deficiency, A Typical Clinical Entity Presenting Myogenic Hyperuricemia
        • Hiromu Nakajima, Norio Kono, Tomoyuki Yamasaki, Kikuko Hotta, Masanori Kawachi, Tomoya Hamaguchi et al.
        Pages 141-144
      11. Amplification of T Cell Activation Induced by CD73 (Ecto-5′Nucleotidase) Engagement
        • Massimo Massaia, Carmela Attisano, Valter Redoglia, Alberto Bianchi, Linda F. Thompson, Umberto Dianzani et al.
        Pages 155-158
      12. Diphosphonucleosides are Indispensable Cofactors of AMP-Specific Cytoplasmic 5′-Nucleotidase Catalysed Reaction
        • Andrzej C. Skladanowski, Paola Miscetti, Andrew C. Newby, Mariusz M. Zydowo
        Pages 163-167
      13. Adenosine Metabolizing Enzymes in Bull and Man Spermatozoa
        • A. Minelli, P. Miscetti, M. Moroni, R. Fabiani, I. Mezzasoma
        Pages 169-171
      14. Cytosolic 5′-Nucleotidase/Phosphotransferase of Human Colon Carcinoma
        • M. G. Tozzi, M. Camici, S. Allegrini, R. Pesi, M. Turriani, A. Del Corso et al.
        Pages 173-176

About this book

These two volumes record the scientific and clinical work presented at the VIIth International and 3rd European joint symposium on purine and pyrimidine metabolism in man held at the Bournemouth International Conference Centre, Bournemouth, UK, from 30th June to 5th July 1991. The series of international meetings at three yearly intervals have previously been held initially in 1973 in Israel, then Austria, Spain, the Netherlands, USA and Japan. The European Society for the Study of Purine and pyrimidine Metabolism in Man (ESSPPM) which has its own executive and some finance first met in switzerland in 1987, then in Germany in 1989. The steady evolution of the science in this series of meetings is intellectually satisfying; the subsequent clinical progress is emotionally and economically reassuring. As befits the position of purines and pyrimidines at the centre of biochemistry, there has been steady scientific development into molecular genetics and now onto developmental controls and biochemical pharmacology. The complexities of the immune system are being unravelled but an understanding of the human brain largely eludes us. Laboratory based scientists now predominate over those who work as clinical specialists in VIi rheumatology, immunology, oncology and paediatrics. However, there continue to be major clinical objectives since large sections are concerned with major causes of death like ATP depletion, cancer and now AIDS; the laboratory work is providing clinical solutions.


  • Colon
  • Nucleotide
  • Purine
  • Pyrimidine
  • biochemistry
  • enzymes
  • metabolism
  • transcription

Editors and Affiliations

  • Institute of Child Health, London, UK

    R. Angus Harkness

  • Burroughs Wellcome Co., Research Triangle Park, USA

    Gertrude B. Elion

  • Universität München, München, Germany

    Nepomuk Zöllner

Bibliographic Information

Buying options

eBook USD 59.99
Price excludes VAT (USA)
  • ISBN: 978-1-4615-7703-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 79.99
Price excludes VAT (USA)