Diet and Breast Cancer

1. Front Matter

   Pages i-xv

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2. Dietary Fat and Breast Cancer: Controversy and Biological Plausibility

   • David P. Rose

   Pages 1-10

3. Dietary Fat Intake Reduction for Patients with Resected Breast Cancer

   • Rowan T. Chlebowski

   Pages 11-23

4. Dietary Fat Reduction as a Hypothesis for the Prevention of Postmenopausal Breast Cancer, and a Discussion of Hypothesis Testing Research Strategies

   • Ross L. Prentice

   Pages 25-33

5. Hormone Studies and the Diet and Breast Cancer Connection

   • Barry R. Goldin, Sherwood L. Gorbach

   Pages 35-46

6. Dietary Fat Effects on Animal Models of Breast Cancer

   • William T. Cave Jr.

   Pages 47-58

7. Effect of Conjugated Linoleic Acid on Carcinogenesis

   • Joseph A. Scimeca, Henry J. Thompson, Clement Ip

   Pages 59-65

8. A Possible Mechanism by Which Dietary Fat Can Alter Tumorigenesis: Lipid Modulation of Macrophage Function

   • Kent L. Erickson, Neil E. Hubbard

   Pages 67-81

9. Dietary Fatty Acids and Human Breast Cancer Cell Growth, Invasion, and Metastasis

   • David P. Rose, Jeanne M. Connolly, Xin-Hua Liu

   Pages 83-91

10. Meta-Analysis of Animal Experiments: Elucidating Relationships Between Dietary Fat and Mammary Tumor Development in Rodents

    • Laurence S. Freedman, Carolyn K. Clifford

    Pages 93-100

11. Vitamin A, Retinoids and Breast Cancer

    • Richard C. Moon

    Pages 101-107

12. Vitamin D Adequacy: A Possible Relationship to Breast Cancer

    • Harold L. Newmark

    Pages 109-114

13. Vitamin D and Breast Cancer

    • Sylvia Christakos

    Pages 115-118

14. Some Aspects of Vitamin E Related to Humans and Breast Cancer Prevention

    • Nikolay V. Dimitrov, Rui-Qin Pan, Jan Bauer, Thomas I. Jones

    Pages 119-127

15. Back Matter

    Pages 129-183

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The fourth annual American Institute for Cancer Research (AICR) conference on diet, nutrition and cancer was held at the L'Enfant Plaza Hotel in Washington, D. C. , September 2~3, 1993. In keeping with present concerns and in line with current trends, the theme was "Diet and Breast Cancer. " This proceedings volume is comprised of chapters from the platform presentations of the two day conference and abstracts from the poster session held at the end of the first day. Experimentally, there is sufficient evidence to support a relationship between dietary fat and the risk of breast cancer. A meta-analysis was provided by data from 114 experiments with over 10,000 animals, divided into groups fed ad libitum on diets with different levels or sources of fat, or different levels of energy restriction. This exercise suggested that linoleic acid was a major determinant of mammary tumor development but that other fatty acids also enhanced mammary tumor development in animals. However, as mentioned by several speakers, results from epidemiological studies often are conflicting, thus leading to confusion among both health professionals and the public. Surveys of specific populations which have migrated from countries with low breast cancer rates to those with higher rates are often some of the most compelling studies with respect to a high fat diet-breast cancer association. Nonetheless, various cohort and prospective studies, some quite large, did not appear to show a relationship between consumption of fat (any type) and breast cancer.

• breast cancer
• cancer
• cancer research
• fat
• health
• nutrition
• tumor

• American Institute for Cancer Research, USA

  Elizabeth K. Weisburger

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