Cardiac Allograft Rejection

1. Front Matter

   Pages i-xvii

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2. Immunopathology of Cardiac Allograft Rejection

   1. Front Matter

      Pages 1-1

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   2. Histocompatibility Antigens and Transplant Rejection

      • Shiv Pillai

      Pages 3-20

   3. Immunology of Cellular and Humoral Rejection after Cardiac Transplantation

      • Marlene L. Rose, Sudhir Kushwaha, Deirdre Cunningham

      Pages 21-47

   4. Immunobiology of Chronic Cardiac Allograft Rejection

      • Petri Koskinen, Jussi Tikkanen, Roope Sihvola, Pekka Häyry, Karl Lemström

      Pages 49-64

   5. Inflammatory Cell Infiltration, Cytokines, and Mechanisms of Myocyte Necrosis in Cardiac Transplant Rejection

      • Jay Bruce Sundstrom, Kimberley Cecile Jollow, Aftab Ahmed Ansari

      Pages 65-88

   6. Apoptosis in Cardiac Transplant Rejection

      • Mireia Puig, Navneet Narula, Jagat Narula

      Pages 89-100

   7. Pathology of Cardiac Allograft Vascular (Microvascular) Rejection: Impact on Patient Outcomes

      • Elizabeth H. Hammond, Robert L. Yowell, Dale G. Renlund

      Pages 101-125

   8. Strategies for the Induction of Allograft Tolerance

      • Thomas Wekerle, Josef Kurtz, Megan Sykes

      Pages 127-151

   9. Xenotransplantation: Hyperacute and Delayed Xenograft Rejection

      • Kwabena Mawulawde, Joren C. Madsen

      Pages 153-173

3. Clinical Assessment and Management of Cardiac Allograft Rejection

   1. Front Matter

      Pages 175-175

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   2. Endomyocardial Biopsy Diagnosis of Cardiac Allograft Rejection

      • Barbara Czerska, Mary E. Keohane, Edward F. Philbin

      Pages 177-196

   3. Clinical Diagnosis and Management of Cardiac Allograft Rejection and Maintenance Immunosuppression

      • Thomas G. Di Salvo, G. William Dec

      Pages 197-232

   4. New Immunosuppressive Agents

      • J. F. Gummert, T. Ikonen, R. E. Morris

      Pages 233-266

   5. Treatment of Acute Vascular Rejection in Cardiac Allografts

      • Ilan S. Wittstein, Edward K. Kasper

      Pages 267-284

4. Newer Diagnostic Tools for the Management of Cardiac Allograft Rejection

   1. Front Matter

      Pages 285-285

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   2. Evolution of Noninvasive Testing for the Detection of Cardiac Allograft Rejection

      • Rohit Srivastava, Jeffrey D. Hosenpud

      Pages 287-297

   3. Echocardiographic Diagnosis of Acute Allograft Rejection

      • Nadia Giannetti, Hannah A. Valantine

      Pages 299-320

   4. The Use of Magnetic Resonance Imaging in Cardiac Transplantation Rejection

      • Todd M. Koelling

      Pages 321-338

5. Radionuclide Imaging for Surveillance of Cardiac Allograft Rejection

   1. Front Matter

      Pages 339-339

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Heart transplantation remains one of the major scientific achievements of twentieth century medicine. During the past four decades, it has evolved from an unproven experimental surgical technique to the most effective form of therapy for refractory end-stage heart disease. It has captured the public's imagination and expanded our understanding of fundamental immunologic mechanisms that are responsible for cellular and humorally-mediated immunity. Despite its successes, many clinical and scientific problems remain. One or more bouts of acute cellular or humoral (vascular) rejection will occur in over 75% of transplant recipients despite current immunosuppressive strategies. Further, rejection directly results in approximately 20% of post-transplant deaths and is believed to play a major role in the development of late allograft dysfunction and coronary vasculopathy.
This book by international experts in the fields of transplantation medicine, immunobiology and cardiac imaging provides the reader with an up-to-date, consise summary of the latest developments in the diagnosis and treatment of acute cardiac rejection. It is axiomatic that a more complete understanding of the pathogenic processes involved in rejection will ultimately lead to its prevention. This volume will be useful to transplant cardiologists, cardiovascular surgeons, cardiac pathologists and transplant scientists who seek to prolong the lifespan and improve the quality of life of their transplant recipients.

• Immunosuppression
• cardiac imaging
• cardiovascular
• heart
• heart transplantation
• transplantation
• thoracic surgery

• Heart Failure & Transplantation Service, Harvard Medical School, Boston, USA

  G William Dec

• Heart Failure/Transplantation Center, Hahnemann University School of Medicine, Philadelphia, USA

  Jagat Narula

• Department of Cardiology, Hospital Universitari Arnau de Vilanova, Universitat de Lleida, Lleida, Spain

  Manel Ballester

• Nuclear Medicine Department, Hospital de Sant Pau, Autonomous University of Barcelona, Barcelona, Spain

  Ignasi Carrio

Policies and ethics